上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (8): 948-.doi: 10.3969/j.issn.1674-8115.2018.08.015

• 综述 • 上一篇    下一篇

Pi3k/Akt信号通路与非典型抗精神病药物作用机制的研究进展

陈艳,张晨   

  1. 上海交通大学医学院附属精神卫生中心生化研究室,上海 200030
  • 出版日期:2018-08-28 发布日期:2018-09-11
  • 通讯作者: 张晨,电子信箱:zhangchen645@gmail.com。
  • 作者简介:陈艳(1993—),女,硕士生;电子信箱: yanc820@163.com。
  • 基金资助:
    国家自然科学基金( 81000581,81471358,81771450);国家临床重点专科 -上海市精神卫生中心(卫计委医政司 2011-873);上海市科学技术发展基金(12140904200);上海市教育委员会高峰高原学科建设计划( 20152530)

Research progress of role of Pi3k/Akt pathway in mechanism of atypical antipsychotic drugs

CHEN Yan, ZHANG Chen   

  1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81000581, 81471358, 81771450; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Funds, 12140904200; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20152530)。

摘要: Pi3k/Akt信号通路在精神分裂症的发病机制中发挥着重要作用,而非典型抗精神病药物对 Pi3k/Akt信号通路具有一定的修饰作用,且该作用已受到研究人员的广泛关注。该文从代谢综合征、免疫功能变化、认知损害、神经保护作用 4个方面,将 Pi3k/Akt信号通路与非典型抗精神病药物作用机制之间关系的研究进展进行综述。

关键词: 非典型抗精神病药物, Pi3k/Akt信号通路, 精神分裂症, 不良反应

Abstract:

The alterations of Pi3k/Akt pathway may be critical in the pathogenesis of schizophrenia. Furthermore, atypical antipsychotic drugs can modify Pi3k/Akt pathway, which have been received wide attention. This review mainly focused on four aspects, i.e. metabolic syndrome, changes in immune function, cognitive impairment and neuroprotective effect, and summarized the research progress of role of Pi3k/Akt pathway in the mechanism of atypical antipsychotic drugs.

Key words: atypical antipsychotic drugs (AAPs), Pi3k/Aktpathway, schizophrenia, adverse reaction

中图分类号: