上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (10): 1214-.doi: 10.3969/j.issn.1674-8115.2019.10.020

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骨质疏松症与肠道菌群间联系的研究进展

李子林1，顾文钦2，沈 恬1   

  1. 1.上海交通大学公共卫生学院，上海200025；2.上海市徐汇区枫林街道社区卫生服务中心，上海200032
  • 出版日期:2019-10-28 发布日期:2019-11-22
  • 通讯作者: 沈 恬，电子信箱：pedyshen@126.com；顾文钦，电子信箱：flsqkfk@163.com。为共同通信作者。
  • 作者简介:李子林（1998—），男，本科生；电子信箱：lzl9841@outlook.com。
  • 基金资助:
    国家自然科学基金（71603167）

Advances in research on relationship between osteoporosis and intestinal microbe

LI Zi-lin1, GU Wen-qing2, SHEN Tian1   

  1. 1. Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China; 2. Fenglin Street Community Health Service Center, Xuhui District, Shanghai, Shanghai 200032, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    National Natural Science Foundation of China, 71603167

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摘要： 骨质疏松症是中老年人群中预后较差的疾病之一，为正常骨转换过程紊乱的结果。目前较多研究表明骨转换与人体内微生物环境息息相关。人体内最多的微生物群存在于肠道中，在机体正常生理活动中扮演着重要角色，起着营养、代谢、免疫及屏障等重要作用。肠道微生物可通过一系列过程调节内分泌及免疫应答，从而影响机体内骨转换的进行。文章简要回顾了目前有关肠道微生物影响机体内骨转换过程的研究，通过探讨骨质疏松症与肠道微生物间联系，为骨质疏松症的治疗提供新思路。

关键词: 骨质疏松症, 骨转换, 肠道微生物

Abstract:

Osteoporosis, one of the severest diseases in the middle-aged and elderly population, is the result of the disorder of the normal bone turnover process. At present, many studies have shown that bone turnover is closely related to the microbial environment in the human body. The largest microbiota in the human body exists in the intestine and plays an important role in the normal physiological activities of the body, such as nutrition, metabolism, immunity and barrier. Intestinal microbe can regulate endocrine and immune system through a series of processes, thereby affecting the process of bone turnover in the body. This article briefly reviews the current research about the effects of intestinal microbe on the process of bone turnover in the body. It is expected to provide new ideas for the treatment of osteoporosisexploring the relationship between osteoporosis and intestinal microbe.

Key words: osteoporosis, bone turnover, intestinal microbe

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