上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (10): 1218-.doi: 10.3969/j.issn.1674-8115.2019.10.021

• 综述 • 上一篇    

盆腔炎鼠类模型构建与评价

覃 倩1，李 彤2，尤剑鹏3，吕 超1，张莉娟1，张 曼2   

  1. 1.广西中医药大学研究生学院，南宁 530001；2.广西中医药大学瑶医学院，南宁 530001；3. 广西中医药大学党委办公室，南宁530001
  • 出版日期:2019-10-28 发布日期:2019-11-22
  • 通讯作者: 尤剑鹏，电子信箱：yjp2816600@163.com。
  • 作者简介:覃 倩（1995—），女，硕士生；电子信箱：544804425@qq.com。
  • 基金资助:
    广西重点研发计划（桂科AB17195015）；广西高校人文社科重点研究基地（0501801705）；广西研究生教育创新计划资助项目（YCSZ2018009）

Rat model construction and evaluation of pelvic inflammatory disease

QIN Qian1, LI Tong2, YOU Jian-peng3, Lü Chao1, ZHANG Li-juan1, ZHANG Man2   

  1. 1. Graduate College of Guangxi University of Traditional Chinese Medicine, Nanning 530001, China; 2. Yao Medical College, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China; 3. Party Committee Office, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    Guangxi Key R & D Program, Guike AB17195015; Guangxi University Humanities and Social Science Key Research Base, 0501801705; Guangxi Graduate Education Innovation Program, YCSZ2018009

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摘要： 盆腔炎是育龄期女性常见的感染之一，其发病机制尚未明确。为探究该病的病理机制，寻找预防和治疗措施，需要建立与人类盆腔炎相类似的动物模型。从实验动物的生物学特性、易获得性、安全性、可重复性、经济性等多方面考虑，鼠类最适合作盆腔炎模型动物。根据盆腔炎的诱导因素，可将其造模方法归纳为生物法造模、物理法造模、化学法造模等几类。根据实验目的、周期、技术等因素，选择合适的模型动物和造模方法是实验成功的关键。文章以鼠类盆腔炎动物模型分类为切入点，对其发病机制、药物剂量、成模时间、适用范围及优缺点进行综述，以期为鼠类盆腔炎模型的选择提供一个参考。

关键词: 盆腔炎, 小鼠, 大鼠, 动物模型

Abstract:

Pelvic inflammatory disease is one of the most common infections in women of childbearing age, and its pathogenesis is not clear. Into explore its pathological pathogenesis and find prevention and treatment measures, it is necessary to establish an animal model similar to human pelvic inflammatory disease. Considering the biological characteristics, availability, safety, repeatability and economy of experimental animals, rats are the most suifor pelvic inflammation model animals. According to the inducing factors of pelvic inflammation, the rat models of pelvic inflammation can be divided into biological modeling, physical modeling, chemical modeling and so on. According to the experimental purpose, experimental cycle, experimental technology and other factors, the selection of appropriate model animals and modeling methods is the key to success. In this paper, the pathogenesis, drug dose, modeling time, applicable scope, advantages and disadvantages of rodent pelvic inflammation animal model are reviewed into provide a reference for the selection of rodent pelvic inflammatory disease model.

Key words: pelvic inflammatory disease, mice, rat, model

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