上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (11): 1530-1535.doi: 10.3969/j.issn.1674-8115.2020.11.017

• 综述 • 上一篇    下一篇

蛋白磷酸酶2A对机体能量代谢影响的研究进展

吴若兰，张 越，俞润华，丁泽宇，黄 莺   

  1. 上海交通大学基础医学院病理生理学系，上海200025
  • 出版日期:2020-11-28 发布日期:2021-01-13
  • 通讯作者: 黄 莺，电子信箱：huangying@shsmu.edu.cn。
  • 作者简介:吴若兰（1998—），女，本科生；电子信箱：lanbeatrice@sjtu.edu.cn。
  • 基金资助:
    国家自然科学基金（81572290）。

Effect of protein phosphatase 2A on energy metabolism

WU Ruo-lan, ZHANG Yue, YU Run-hua, DING Ze-yu, HUANG Ying   

  1. Department of Pathophysiology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    National Natural Science Foundation of China (81572290).

PDF (PC)

307

摘要： 蛋白磷酸酶2A（protein phosphatase 2A，PP2A）是一种丝/苏氨酸磷酸酶，由A、B、C共3种亚基组成。研究显示，PP2A可通过催化蛋白质的去磷酸化反应，参与多种酶及转录因子的调控，在能量代谢、DNA损伤与修复、蛋白质翻译、细胞周期调控和信号转导等方面发挥重要作用。该文就PP2A的结构与调控、对能量代谢的影响以及在相关疾病发生中的作用进行综述。

关键词: 蛋白磷酸酶2A, 能量代谢, 蛋白激酶B, 哺乳动物雷帕霉素靶蛋白复合物, 叉头转录因子1

Abstract:

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase consisting of three subunits, namely A, B and C. Studies have shown that PP2A plays an important role in energy metabolism, DNA damage and repair, protein translation, cell cycle regulation and signal transduction by catalyzing the dephosphorylation of proteins and participating in the regulation of a variety of enzymes and transcription factors. This article reviews the structure and regulation of PP2A, its effect on energy metabolism and the occurrence of related diseases.

Key words: protein phosphatase 2A (PP2A), energy metabolism, protein kinase B (PKB, Akt), mammalian target of rapamycin complex (mTORC), forkhead box O1 (FoxO1)

中图分类号: