上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (11): 1536-1539.doi: 10.3969/j.issn.1674-8115.2020.11.018

• 综述 • 上一篇    下一篇

Hippo信号通路调节卵巢物质代谢对卵巢功能影响的研究进展

李 佳1, 2，袁树晟3，曹秀萍4，王心男5，黄 健1, 6，郑月慧2, 6   

  1. 1. 南昌大学医学实验教学中心，南昌 330006；2. 江西省生殖生理与病理重点实验室，南昌 330006；3. 南昌大学第四临床医学院，南昌 330006；4. 南昌大学基础医学院生物系，南昌 330006；5. 南昌大学第二临床医学院，南昌 330006；6. 深圳市中医院生殖健康科，深圳 518000
  • 出版日期:2020-11-28 发布日期:2021-01-13
  • 通讯作者: 郑月慧，电子信箱: yuehuizheng@163.com。
  • 作者简介:李 佳（1986—），女，讲师，博士；电子信箱：lijia4199@163.com。
  • 基金资助:
    江西省自然科学基金（20192BAB215009，20202ACB216003）；南昌大学科研训练项目（1003-31080002）。

Research progress of ovarian function regulated by ovarian material metabolism through Hippo signaling pathway

LI Jia1, 2, YUAN Shu-sheng3, CAO Xiu-ping4, WANG Xin-nan5, HUANG Jian1, 6, ZHENG Yue-hui2, 6   

  1. 1. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China; 2. Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang 330006, China; 3. The Fourth Clinical Medical School of Nanchang University, Nanchang 330006, China; 4. Basic Medical School, Nanchang University, Nanchang 330006, China; 5. The Second Clinical Medical School of Nanchang University, Nanchang 330006, China; 6. Department of Reproductive Health, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    Natural Science Foundation of Jiangxi Province (20192BAB215009, 20202ACB216003); Research and Training Program of Nanchang University (1003-31080002).

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摘要： Hippo信号通路存在于果蝇和哺乳动物中，主要由上游调节分子、核心成分及下游调节分子组成，具有调控细胞增殖、分化及细胞周期等生理作用。近年来已有研究表明，Hippo信号通路单独或协同AMP活化蛋白激酶（AMP-activated protein kinase，AMPK）信号通路、哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）信号通路参与三大物质代谢，包括葡萄糖代谢、甲羟戊酸代谢和谷氨酰胺代谢。Hippo信号通路与卵巢物质代谢的关系是近几年兴起的研究热点。该文就Hippo信号通路通过单独或协同AMPK信号通路、mTOR信号通路调节卵巢的三大物质代谢过程，参与卵泡的生长、成熟及多囊卵巢综合征、卵巢癌的发生等的研究进展作一综述。

关键词: Hippo信号通路, 卵巢功能, 物质代谢, AMP活化蛋白激酶信号通路, 哺乳动物雷帕霉素靶蛋白信号通路

Abstract:

Hippo signaling pathway exists in drosophila and mammals, which is mainly composed of upstream modulators, core components and downstream modulators and has physiological functions such as cell proliferation, differentiation and cell cycle. In recent years, some research has shown that the Hippo signaling pathway can participate in three major substances, including glucose metabolism, mevalonate metabolism and glutamine metabolism, either alone or in combination with the AMP-activated protein kinase (AMPK) signaling pathway and the mammalian target of rapamycin (mTOR) signaling pathway. The relationship between Hippo signaling pathway and ovarian material metabolism is a research hotspot that has emerged in recent years. In this review, we summarize research progress that the Hippo signaling pathway regulates the maturation of follicles, polycystic ovary syndrome and ovarian cancer, through either alone or in combination with the AMPK signaling pathway and the mTOR signaling pathway.

Key words: Hippo signaling pathway, ovary function, material metabolism, AMPK signaling pathway, mTOR signaling pathway

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