上海交通大学学报（医学版）

上海交通大学学报（医学版）

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成人迟发型自身免疫性糖尿病发病机制研究进展

鲁 郡，侯旭宏，贾伟平   

  1. 上海交通大学附属第六人民医院内分泌代谢科 上海市糖尿病研究所 上海市糖尿病重点实验室 上海市糖尿病临床医学中心， 上海 200233
  • 出版日期:2014-04-28 发布日期:2014-05-13
  • 作者简介:鲁 郡（1981—）， 男， 博士生; 电子信箱: lujundoctor@163.com。

Advances of pathogenesis of latent autoimmune diabetes in adults

LU Jun, HOU Xu-hong, JIA Wei-ping   

  1. Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-04-28 Published:2014-05-13

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摘要：

成人迟发型自身免疫性糖尿病（LADA）是成人发病的缓慢进展的自身免疫性糖尿病，其起病特点与2型糖尿病（T2DM）相似，占我国新诊断T2DM患者的5.9%~9.2%。LADA的发病机制是近年来研究热点之一，在遗传易感基因、自身免疫反应以及环境因素等方面的研究取得了一定进展，发现非人类白细胞抗原基因（HLA）、细胞免疫和非特异性免疫反应等与LADA有关。深入研究LADA的发病机制有助于阐明LADA发病和临床特点，对疾病的早期预防和诊断、合理治疗以及探索新的治疗方法等均有积极作用。

关键词: 迟发型自身免疫性糖尿病, 易感基因, 体液免疫, 细胞免疫, 环境因素

Abstract:

Latent autoimmune diabetes in adults (LADA) is a form of adult-onset autoimmune diabetes that resembles type 2 diabetes. However, it shows a later onset and slowly progression towards insulin requirement. LADA accounts for 5.9% to 9.2% in newly diagnosed patients with phenotypic type 2 diabetes in China. The pathogenesis of LADA has become one of the hot research topics in recent years. Progresses have been made in aspects such as genetic susceptibility, autoimmune reaction, and environmental factors and so on. Studies show that non-HLA gene, cellular immunity, and nonspecific immune reaction etc. are relevant to LADA. Thorough research on the pathogenesis of LADA is helpful for understanding it's clinical characteristics, early prevention and diagnosis, proper treatment, and even exploring new therapeutic methods.

Key words: latent autoimmune diabetes in adults, susceptibility gene, humoral immunity, cellular immunity, environmental factors