上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

血浆胆固醇水平与血浆β-淀粉样蛋白水平的相关性研究

吕 鹏1，胡亚楠2，盛宏光3   

  1. 1.上海交通大学 医学院附属仁济医院老年科， 上海 200127； 2.中国科学院上海生命科学研究院营养科学研究所临床研究中心， 上海 200031； 3.上海市徐汇区中心医院内分泌科， 上海 200031
  • 出版日期:2014-09-28 发布日期:2014-09-26
  • 作者简介:吕 鹏（1985—）， 女， 主治医师， 硕士生; 电子信箱: lvpeng0061@163.com。

Study on correlation of plasma cholesterol level and amyloid β level

LÜ Peng1, HU Ya-nan2, SHENG Hong-guang3   

  1. 1.Department of Geriatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Clinical Research Center, Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 3.Department of Endocrinology, Shanghai Xuhui District Central Hospital, Shanghai 200031， China
  • Online:2014-09-28 Published:2014-09-26

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摘要：

目的 探讨血浆胆固醇水平与血浆β-淀粉样蛋白（Aβ）水平的关系。方法 在50～65岁年龄段，随机选取16例胆固醇边缘升高和16例胆固醇升高患者作为高胆固醇组，并随机选择16例胆固醇正常个体作为正常对照组，分别测定两组中血浆Aβ-40、Aβ-42、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和三酰甘油(TG)的浓度，并分析其相关性。结果 高胆固醇组血浆Aβ-40、Aβ-42水平均显著高于正常对照组(P<0.01)，同时高胆固醇组LDL-C和TG也显著高于正常对照组(P<0.01)。直线相关性分析发现，正常对照组Aβ-40、Aβ-42与TC、LDL-C、HDL-C、TG均无相关性，高胆固醇组Aβ-40、Aβ-42均与TC呈正相关(P<0.01或P<0.05)。高胆固醇组TC与TG、LDL-C呈正相关(P<0.01或P<0.05)，与HDL呈负相关(P<0.05)。校正TG、LDL-C和HDL-C后，对TC与Aβ-40、Aβ-42行偏相关分析，结果显示血浆Aβ-40、Aβ-42仍与TC呈正相关(P<0.05)。结论 血浆Aβ-40、Aβ-42水平在高胆固醇个体中显著升高；在高胆固醇个体中，血浆Aβ水平与血浆胆固醇水平存在相关性。

关键词: β-淀粉样蛋白, 胆固醇, 相关性

Abstract:

Objective To explore the correlation of the plasma cholesterol level and the plasma amyloid β (Aβ) level. Methods Among patients aged 50-65 years, 16 patients with borderline high cholesterol and 16 patients with high cholesterol were randomly selected as the high cholesterol group and 16 healthy subjects were randomly selected as the control group. The levels of plasma Aβ-40, Aβ-42, total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) of two groups were detected and their correlations were analyzed. Results The levels of plasma Aβ-40, Aβ-42, LDL-C, and TG of the high cholesterol group were significantly higher than those of the control group (P<0.01). The linear correlation analysis showed that for the control group, Aβ-40 and Aβ-42 did not correlate with TC, LDL-C, HDL-C, and TG. For the high cholesterol group, Aβ-40 and Aβ-42 positively correlated with TC (P<0.01 or P<0.05), and TC positively correlated with TG and LDL-C (P<0.01 or P<0.05) and negatively correlated with HDL (P<0.05). After TG, LDL-C, and HDL-C were adjusted, partial correlation analysis was performed for TC versus Aβ-40 and Aβ-42. The results showed that Aβ-40 and Aβ-42 still positively correlated with TC (P<0.05). Conclusion For patients with high cholesterol, the levels of plasma Aβ-40 and Aβ-42 significantly increase and the plasma Aβ level is correlated with plasma TC level.

Key words: amyloid β, cholesterol, correlation