上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

患者对于生物样本捐赠态度的横断面调查研究

丁文彬，马 逸，王 晔，费 辛，王 青，于维杰，仓艺倩，戴慧莉   

  1. 上海交通大学 医学院附属仁济医院科研处， 上海 200127
  • 出版日期:2014-10-28 发布日期:2014-10-28
  • 通讯作者: 戴慧莉, 电子信箱: daihuili@renji.com。
  • 作者简介:丁文彬(1970—)， 男， 工程师， 硕士; 电子信箱: wbding@shsmu.edu.cn。
  • 基金资助:

    上海交通大学医学院校级文科课题

Cross-sectional survey of attitudes of patients towards biosample donation

DING Wen-bin, MA Yi, WANG Ye, FEI Xin, WANG Qing, YU Wei-jie, CANG Yi-qian, DAI Hui-li   

  1. Department of Science, Technology, and Education, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2014-10-28 Published:2014-10-28
  • Supported by:

    Liberal Arts Subject of Shanghai Jiao Tong University School of Medicine

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摘要：

目的 调查患者对临床样本捐赠及使用等相关问题的态度和影响因素。方法 设计生物样本捐赠调查问卷,在上海交通大学医学院附属仁济医院随机选取639例患者作为调查对象，对患者捐赠生物样本的意愿、动机、捐赠样本的用途、期望研究结果反馈以及对医疗机构的信任度等情况进行调查和统计分析。结果 本次调查应答率81.7%。被调查者中有66.7%愿意捐赠样本，其中40.8%表示只愿意匿名捐献样本；17.2%的人希望捐赠后随时可撤回；信任或非常信任医疗机构的患者有42.3%；年轻、高学历的患者捐赠意愿较高（P<0.05），乙肝病毒携带者捐献同意率（26.7%）明显低于非携带者（70.4%）（P<0.05）。结论 相比国外我国生物样本捐赠意愿较低。患者受教育程度及对医疗机构的信任程度可能是影响捐赠的主要因素。本次调查有利于了解患者对生物样本捐献的真实态度及想法，提高患者对于生物样本使用和临床研究意义的认知，增强患者对生物样本捐赠的意愿，促进我国生物样本库的伦理法规建设。

关键词: 患者, 生物样本, 捐赠, 意愿

Abstract:

Objective To investigate the attitudes of patients towards the donation and usage of clinical biosamples and their affecting factors. Methods Questionnaires of donation of clinical biosamples were prepared and 639 patients in Renji Hospital of Shanghai Jiao Tong University School of Medicine were randomly selected. The attitudes and motivation of patients towards donating clinical biosamples, usage of biosamples, expectations for feedback of research results, and trust in medical institutions were investigated and statistically analyzed. Results The response rate was 81.7%. And 66.7% of respondents would donate biosamples and 40.8% of them would donate anonymously; 17.2% of respondents desired that they could withdraw their donations anytime afterwards; and 42.3% of respondents trusted or strongly trusted medical institutions. The donation rate of young respondents with high education levels was high (P<0.05). The donation rate of patients with hepatitis B was significantly lower than that of other patients (26.7% vs 70.4%, P<0.05). Conclusion The willingness of Chinese patients to donate biosamples is lower than that of patients of other countries. The trust level of patients towards medical institutions and their education levels may be the main factors affecting the donation. The survey is helpful for understanding the real attitudes of patients towards biosample donation, improving their awareness of usage of and clinical research on biosamples, enhancing their willingness of biosample donation, and promoting the development of ethical laws for biobanks of China.

Key words: patient, biosample, donation, attitude