上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

CD64指数在新生儿脓毒症早期诊断中的意义

阮莉莉1，杜俊君2，林 艳1，楼红萍1   

  1. 1.杭州师范大学附属医院儿科， 杭州 310015; 2.苏州市立医院儿科， 苏州 215008
  • 出版日期:2014-10-28 发布日期:2014-10-28
  • 作者简介:阮莉莉(1970—)， 女， 副主任医师， 学士; 电子信箱: ruanlili2013@126.com。

Significance of CD64 index for early diagnosis of neonatal sepsis

RUAN Li-li1, DU Jun-jun2, LIN Yan1, LOU Hong-ping1   

  1. 1.Department of Pediatrics, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China； 2.Department of Pediatrics, Suzhou Municipal Hospital， Suzhou 215008， China
  • Online:2014-10-28 Published:2014-10-28

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摘要：

目的 评估CD64指数在新生儿脓毒症早期诊断中的意义。方法 采用前瞻性病例对照研究方法进行分析。41例新生儿患儿分为确诊脓毒症组（n=14）、临床脓毒症组（n=15）和对照组（n=12），各组患儿均在入院24 h内采集静脉血样，采用流式细胞术检测CD64指数。结果 流式细胞仪检测结果显示：确诊脓毒症组、临床脓毒症组和对照组的CD64 指数分别为12.93±4.08，9.51±2.21和2.98±0.72。与对照组比较，确诊脓毒症组和临床脓毒症组CD64指数显著增高（t=8.97，P=0.00；t=6.27，P=0.00）；确诊脓毒症组CD64指数显著高于临床脓毒症组（t=2.39，P=0.023）。结论 CD64指数的检测有助于新生儿脓毒血症的早期诊断，并可区分感染的严重程度，为临床正确治疗提供重要依据。

关键词: 脓毒症, CD64, 流式细胞术, 新生儿

Abstract:

Objective To evaluate the significance of the CD64 index for the early diagnosis of neonatal sepsis. Methods The prospective case-control study was adopted to conduct the analysis. A total of 41 neonatal patients were divided into the documented sepsis group (n=14), clinical sepsis group (n=15), and control group (n=12). Venous blood specimens of all patients were collected with in 24 h after admission. The CD64 index was measured by the flow cytometry. Results Results of the flow cytometry showed that the CD64 indexes of the documented sepsis group, clinical sepsis group, and control group were 12.93±4.08, 9.51±2.21, and 2.98±0.72, respectively. Compared to the control group, the CD64 indexes of the documented sepsis group and clinical sepsis group were significantly higher (t=8.97, P=0.00; t=6.27, P=0.00). The CD64 index of the documented sepsis group was significantly higher than that of the clinical sepsis group (t=2.39，P=0.023). Conclusion Detection of CD64 contributes to the early diagnosis of neonatal sepsis, identifies the degree of infection, and provides an important evidence for appropriate clinical treatment.

Key words: sepsis, CD64, flow cytometry, newborn