上海交通大学学报（医学版）

上海交通大学学报（医学版）

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肠道菌群与肥胖及相关代谢性疾病关系的研究进展

朱超霞，陆颖理   

  1. 上海交通大学 医学院附属第九人民医院内分泌科， 上海 200011
  • 出版日期:2014-12-28 发布日期:2014-12-30
  • 通讯作者: 陆颖理, 电子信箱: luyingli2008@126.com。
  • 作者简介:朱超霞（1987—）， 女， 硕士生; 电子信箱: zhuchaoxia2012@163.com。
  • 基金资助:

    国家重点基础研究发展计划（“973”计划）（2012CB524906）

Advances of relationships among gut microbiota, obesity, and metabolic diseases relevant to obesity

ZHU Chao-xia, LU Ying-li   

  1. Department of Endocrinology, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2014-12-28 Published:2014-12-30
  • Supported by:

    National Basic Research Program of China, “973”Program， 2012CB524906

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摘要：

肥胖的发病率正在世界范围内上升，已成为威胁人类健康和降低人类生活质量的全球性疾病。作为一种遗传因素、环境因素及生活方式相互作用的复杂疾病，肥胖会引起高脂血症、高血压、心血管疾病、代谢综合征和非乙醇性脂肪性肝病等疾病。肠道菌群的代谢活动影响着宿主的营养、代谢及免疫功能等，是影响肥胖及相关代谢性疾病的一个重要的环境因素。文章主要就肠道菌群与肥胖及相关代谢性疾病的关系及作用机制进行综述。

关键词: 肥胖, 肠道菌群, 慢性炎症, 代谢性疾病

Abstract:

The incidence of obesity is on the rise globally. Obesity has become a global disease that threatens human health and reduces the quality of human life. As a complicated disease affected by the interaction of genetic factors, environmental factors, and lifestyle, obesity can cause diseases such as hyperlipidemia, hypertension, cardiovascular diseases, metabolic syndrome, and non-alcoholic fatty liver disease. Metabolic activities of gut microbiota affect nutrition, metabolism, and immune functions of the host. Therefore, gut microbiota is an important environmental factor affecting obesity and metabolic disorders relevant to obesity. This paper reviews the relationships among gut microbiota, obesity, and metabolic disorders relevant to obesity and their affecting mechanisms.

Key words: obesity, gut microbiota, chronic inflammation, metabolic diseases