上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

血同型半胱氨酸与脑白质疏松的关系

陈雅芳1，黄银辉2，蔡若蔚1，林友榆2，陈海默2，卓识途1，张碧月1，张金英1   

  1. 1.福建医科大学附属第二医院神经内科， 泉州 362000； 2.晋江市医院神经内科， 晋江 362200
  • 出版日期:2015-08-28 发布日期:2015-09-30
  • 作者简介:陈雅芳（1986—）， 女， 住院医师， 硕士; 电子信箱: 10414246@qq.com。

Relationship between serum homocystein and leukoaraiosis

CHEN Ya-fang1, HUANG Yin-hui2, CAI Ruo-wei1, LIN You-yu2, CHEN Hai-Mo2, ZHUO Shi-tu1, ZHANG Bi-yue1, ZHANG Jin-ying1   

  1. 1.Department of Neurology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; 2.Department of Neurology, Jinjiang City Hospital, Jinjiang 362200, China
  • Online:2015-08-28 Published:2015-09-30

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摘要：

目的  探讨血同型半胱氨酸与脑白质疏松的关系。方法  选取2013年5月至2014年5月连续收治的脑白质疏松患者作为研究对象。根据有无脑白质疏松，分为脑白质疏松组和无脑白质疏松组，其中脑白质疏松组164例，无脑白质疏松组104例。收集两组患者临床资料（性别、年龄、高血压、糖尿病、吸烟、饮酒、血脂、血浆纤维蛋白原、空腹血糖、D二聚体、尿酸、白蛋白、血同型半胱氨酸水平等），采用单因素和Logistic回归分析脑白质疏松相关危险因素。结果  脑白质疏松组与无脑白质疏松组相比，血同型半胱氨酸水平较高，为（15.57±6.22）μmol/L，无脑白质疏松组为（12.74±4.93）μmol/L，两者间差异具有统计学意义（P<0.001）。经Logistic多因素回归分析，血同型半胱氨酸(P=0.041；OR：1.118；95%CI：1.004~1.245)与脑白质疏松的发生独立相关。结论  高血同型半胱氨酸血症是脑白质疏松的独立危险因素。

关键词: 血同型半胱氨酸, 脑白质疏松, 危险因素

Abstract:

Objective  To explore the relationship between serum homocysteine (Hcy) and leukoaraiosis (LA). Methods  Patients with LA who were admitted and treated from May 2013 to May 2014 were selected as subjects and divided into LA group (n=164) and non-LA group (n=104) according to the incidence of LA. Clinical data of two groups (gender, age, hypertension, diabetes, smoking, alcohol consumption, blood lipid, plasma fibrinogen, fasting blood glucose, D-dimer, uric acid, albumin, and Hcy) were collected. Univariate analysis and multivariate logistic regression analysis were used to analyze risk factors relevant to LA. Results  Hcy levels of LA group [(15.57±6.22) μmol/L] were higher than those of non-LA group [(12.74±4.93) μmol/L] and the difference between two groups was statistically significant (P<0.001). The multivariate Logistic regression analysis showed that Hcy (P=0.041; OR: 1.118; 95%CI: 1.004-1.245) was independently correlated with the incidence of LA. Conclusion  Hcy is an independent risk factor of leukoaraiosis.

Key words: homocystein, leukoaraiosis, risk factor