上海交通大学学报(医学版) ›› 2015, Vol. 35 ›› Issue (10): 1516-.doi: 10.3969/j.issn.1674-8115.2015.10.017

• 论著(临床研究) • 上一篇    下一篇

精神分裂症认知功能与症状转归的相关性研究

曹爱爱1,2,张洁1,黄佳1,朱娜1,张天宏1,高荣新1,张莉1,邱美慧1,彭代辉1,徐一峰1   

  1. 1.上海交通大学 医学院附属精神卫生中心, 上海200030; 2.上海市长宁区精神卫生中心, 上海200335
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 徐一峰, 电子信箱: hyyyyb@gmail.com; 彭代辉, 电子信箱: pdhsh@126.com
  • 作者简介:曹爱爱(1986—), 女, 住院医师, 硕士; 电子信箱: aimichelle44@126.com
  • 基金资助:

    上海市卫生局科研课题(2010086,2011-2013);上海交通大学“医工交叉研究基金”项目(YG2012MS11)

Correlation between cognitive function and symptom changes of patients with schizophrenia

CAO Ai-ai 1,2, ZHANG Jie1, HUANG Jia1, ZHU Na1, ZHANG Tian-hong1, GAO Rong-xin1, ZHANG Li1, QIU Mei-hui1, PENG Dai-hui1, XU Yi-feng1   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 2.Shanghai Changning District Mental Health Center, Shanghai200335, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Foundation of Shanghai Municipal Health Bureau, 2010086, 2011-2013; Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2012MS11

摘要:

目的通过随访精神分裂症患者治疗后认知功能,探索精神分裂症认知功能特征与临床症状转归之间的相关性。方法选择符合ICD-10诊断标准的精神分裂症患者30例,首次发作,均给予利培酮治疗,用认知功能成套测验-共识版(MCCB)工具测试认知功能的全部7个维度因子,以阳性及阴性精神症状量表(PANSS)评估症状。随访1年后,再次进行MCCB测定以及PANSS评估。结果19例患者完成1年的随访。精神分裂症患者治疗前后,在言语学习与记忆维度因子上,差异具有统计学意义(P<0.05),其余6个认知维度因子的改变无统计学意义。治疗随访1年后,精神分裂症患者的阳性症状、阴性症状及一般病理症状均显著改善(P<0.05),临床症状中的一般病理因子维度中的先占观念与主动回避社交因子与其认知功能中言语学习与记忆的缓解呈正相关(P<0.05)。结论药物治疗前后,精神分裂症患者在言语学习与记忆方面有所改变,这种改变与患者的先占观念和主动回避社交症状的转归相关。

关键词: 精神分裂症, 认知功能, 认知功能成套测验

Abstract:

ObjectiveTo explore the correlation between characteristics of the cognitive function and changes of clinical symptoms of patients with schizophrenia by follow-up of the cognitive function study of patients with schizophrenia after treatment.MethodsA total of 30 patients with schizophrenia of first episode who met the criteria of ICD-10 were enrolled. All patients were treated with risperidone. MATRICS consensus cognitive battery (MCCB) tool was used to test all seven dimensions of the cognitive function and Positive and Negative Syndrome Scale (PANSS) was adopted to assess mental symptoms of patients.MCCB test and PANSS assessment were conducted after one year of follow-up.ResultsA total of 19 patients were followed up for one year. The differences of verbal learning and memory of patients with schizophrenia before and after treatment were statistically significant (P<0.05). Changes of other six dimensions of the cognitive function were not statistically significant. The positive, negative, and general psychopathological symptoms of patients with schizophrenia were significantly alleviated one year after treatment (P<0.05). The preemptive concept and active social withdrawal of the general psychopathological factor of clinical symptoms positively correlated with verbal learning and memory of cognitive function (P<0.05). ConclusionThe verbal learning and memory of patients with schizophrenia have changed before and after treatment, which are relevant to the changes of preemptive concept and active social withdrawal.

Key words: schizophrenia, cognitive function, MATRICS consensus cognitive battery