上海交通大学学报（医学版）

上海交通大学学报（医学版）

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血管紧张素Ⅱ-2型受体在心血管疾病炎症反应中的作用

杜明君，连锋，薛松   

  1. 上海交通大学  医学院附属仁济医院心血管外科, 上海 200127
  • 出版日期:2016-05-28 发布日期:2016-05-26
  • 作者简介:杜明君（1989—）， 男， 硕士生; 电子信箱: 919402904@qq.com。
  • 基金资助:

    上海市科委医学引导项目（124119a2100）

Effects of angiotensin Ⅱ type-2 receptor on inflammatory reactions in cardiovascular diseases

DU Ming-jun, LIAN Feng, XUE Song   

  1. Department of Cardiovascular Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality,124119a2100

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摘要：

心血管疾病多伴有慢性炎症反应。肾素—血管紧张素系统（RAS）参与心血管炎症的发生和发展，血管紧张素Ⅱ（ANGⅡ）的炎症作用主要通过其1型受体（AT1受体）实现。相较于AT1受体，人们对ANGⅡ 2型受体（AT2受体）的了解还不是很深入。近年来发现AT2受体也参与许多心血管疾病炎症反应进程，激活AT2受体能从不同层面抑制炎症的发展。该文就AT2受体参与调节心血管系统炎症反应的机制作一综述。

关键词: 血管紧张素Ⅱ, AT2受体, 炎症, 心血管疾病

Abstract:

Most cardiovascular diseases are associated with chronic inflammatory reactions. The rennin angiotensin system (RAS) is involved in occurrence and development of the cardiovascular inflammation. The inflammatory effect of angiotensin Ⅱ (Ang II) is mainly achieved via the AngⅡ type-1 (AT1) receptor. However, Ang Ⅱ type-2 (AT2) receptor is less well understood as compared with AT1 receptor. Recent studies have found that AT2 receptor also participates in the inflammatory reaction process of many cardiovascular diseases. Stimulated AT2 receptor can inhibit the development of inflammation at different levels. This paper reviews mechanism of the involvement of AT2 receptor in regulating inflammatory reactions of cardiovascular system.

Key words: angiotensin Ⅱ, AT2 receptor, inflammation； cardiovascular diseases