上海交通大学学报（医学版）
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张沥文，王伟铭
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ZHANG Li-wen, WANG Wei-ming
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摘要：
免疫球蛋白A（IgA）肾病是目前世界范围内最常见的原发性肾小球疾病。糖基化缺陷的IgA1分子引起自身免疫反应，是IgA肾病发病的始动机制。近年来，在IgA肾病发病机制和标志物方面的研究取得了显著进展，这为IgA肾病的非侵入性诊断、疾病活动监测和疾病特异性治疗提供了基础。该文就IgA肾病发病的分子机制和重要血清标志物的研究进展作一综述。
关键词: 免疫球蛋白A肾病, 发病机制, 血清标志物
Abstract:
Immunoglobulin A (IgA) nephropathy is the most prevalent primary chronic glomerular disease worldwide. The autoimmune response caused by galactose-deficient polymeric IgA1 is the original mechanism triggering the IgA nephropathy. Significant research advances in pathogenesis and biomarkers of IgA nephropathy have been made in recent years and provide the basis for noninvasive diagnosis, monitoring of disease activity, and disease-specific therapies. The research advances in molecular mechanisms and key serum biomarkers in the pathogenesis of IgA nephropathy are reviewed in this paper.
Key words: immunoglobulin A nephropathy, pathogenesis, serum biomarkers
张沥文，王伟铭. 免疫球蛋白A肾病发病机制及相关血清标志物[J]. 上海交通大学学报（医学版）, doi: 10.3969/j.issn.1674-8115.2016.06.031.
ZHANG Li-wen, WANG Wei-ming. Pathogenesis and relevant serum biomarkers of immunoglobulin A nephropathy[J]. , doi: 10.3969/j.issn.1674-8115.2016.06.031.
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链接本文: https://xuebao.shsmu.edu.cn/CN/10.3969/j.issn.1674-8115.2016.06.031
https://xuebao.shsmu.edu.cn/CN/Y2016/V36/I06/939
