上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（临床研究） • 上一篇    下一篇

失代偿期肝硬化患者血清中前列腺素E2水平对感染的预测价值研究

黄小平，王艳，孙蔚，黄燕，陈丽，甘建和   

  1. 苏州大学 附属第一医院感染科， 苏州 215006
  • 出版日期:2016-07-28 发布日期:2016-08-31
  • 通讯作者: 甘建和, 电子信箱: ganjianhe@aliyun.com。
  • 作者简介:黄小平（1979—）， 男， 主治医师， 硕士; 电子信箱: grehxp@163.com。
  • 基金资助:

    国家科技部“十二五”重大专项(2012X10002004-008)

Study on the value of serum PGE2 in patients with cirrhosis in decompensation stage for predicting infections

HUANG Xiao-ping, WANG Yan, SUN Wei, HUANG Yan, CHEN Li, GAN Jian-he   

  1. Department of Infectious Disease, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China
  • Online:2016-07-28 Published:2016-08-31
  • Supported by:

    Major Science and Technology Program of Ministry of Science and Technology in the National “12th 5-year Plan” of China, 2012X10002004-008

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摘要：

目的 检测失代偿期肝硬化患者血清中前列腺素E2（PGE2）的水平，并探讨其在预测感染风险的价值。方法 用ELISA法检测167例失代偿期肝硬化患者（分为未感染组133例，感染组34例）及65例代偿期肝硬化患者（对照组）血清PGE2的水平，分析其在肝硬化患者发生感染风险的预测价值。结果 失代偿期肝硬化感染组和未感染组血清PGE2水平均显著高于对照组（P=0.000 0）；而感染组血清PGE2显著高于未感染组（P=0.000 0）。PGE2在预测肝硬化感染风险ROC曲线的曲线下面积（AUC）为0.82（95%CI为0.76～0.90）；当PGE2为2 637 pg/mL时，其预测失代偿期肝硬化患者发生感染的灵敏度和特异度分别为0.824和0.777。结论 PGE2可以在一定程度上反映失代偿期肝硬化患者的免疫功能状态，其水平增高提示发生感染的风险增加。

关键词: 肝硬化, 感染, 免疫缺陷, 前列腺素E2

Abstract:

Objective To measure the serum PGE2 level in patients with cirrhosis in decompensation stage and explore the value for predicting the risk of infections. Methods Serum PGE2 levels in 167 patients with cirrhosis in decompensation stage who were assigned to the non-infection group (n=133) and the infection group (n=34) and 65 patients with cirrhosis in compensation stage (the control group) were measured with ELISA. The value for predicting the risk of infections in patients with cirrhosis was analyzed. Results Significantly higher PGE2 levels were found in the non-infection group and the infection group than that in the control group (P=0.000 0). The PGE2 levels were significantly higher in the infection group than that in the non-infection group (P=0.000 0). The area under the receiver operating characteristic curve for predicting the risk of infections was 0.82 (95%CI: 0.76-0.90). The sensitivity and specificity of PGE2 of 2 637 pg/mL for predicting the infections in patients with cirrhosis in decompensation stage were 0.824 and 0.777， respectively. Conclusion PGE2 can reflect the state of immune function in patients with cirrhosis in decompensation stage to a certain extent. Increased PGE2 level suggests a higher risk of infections.

Key words: cirrhosis, infection, immunodeficiency, prostaglandin E2