上海交通大学学报（医学版）

上海交通大学学报（医学版）

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卵巢癌相关成纤维细胞的研究进展

卜时夏，赖东梅   

  1. 上海交通大学 医学院附属国际和平妇幼保健院，上海 200030
  • 出版日期:2016-08-29 发布日期:2016-08-31
  • 通讯作者: 赖东梅，电子信箱：laidongmei@hotmail.com。
  • 作者简介:卜时夏（1991—），男，硕士生；电子信箱：bushixia_sjtu@163.com。
  • 基金资助:

    上海市教育委员会高峰高原学科建设计划（20152236)；上海市科学技术委员会项目（14411961500）；国家自然科学基金（81370678）

An update about role of ovarian cancer-associated fibroblasts

BU Shi-xia, LAI Dong-mei   

  1. The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support，20152236；Project of Shanghai Municipal Science and Technology Commission，14411961500；National Natural Science Foundation of China，81370678

PDF (PC)

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摘要：

上皮性卵巢癌是女性生殖系统肿瘤中病死率最高的恶性肿瘤。肿瘤微环境内卵巢癌细胞与卵巢癌相关成纤维细胞间的交互影响在肿瘤的发展中起到了重要的作用。该文综述了卵巢癌相关成纤维细胞的最新研究进展，包括起源、在卵巢癌恶性进展中的作用、在卵巢癌诊断及预后评估中的价值，并探讨卵巢癌相关成纤维细胞作为潜在治疗靶点的可能。

关键词: 卵巢癌, 肿瘤微环境, 肿瘤相关成纤维细胞

Abstract:

Epithelial ovarian cancer (EOC) remains the leading cause of gynecological cancer-related death. In the tumor microenvironment, the reciprocal inter-communication between ovarian cancer cells and ovarian cancer-associated fibroblasts (OCAFs) plays an important role in the progression of ovarian cancer. This review discusses the latest research progresses about OCAFs, including their possible origins, their effects on the progression of ovarian cancer, the potential diagnostic and predictive value of OCAFs, and the potential of OCAF-targeted therapy.

Key words: ovarian cancer, tumor microenvironment, cancer-associated fibroblasts