上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 847-.doi: 10.3969/j.issn.1674-8115.2017.06.023

• 综述 • 上一篇    下一篇

基于构建抗感染骨科植入物的钛表面纳米化修饰和载药的不同方式

李晖，聂彬恩，岳冰   

  1. 上海交通大学 医学院附属仁济医院骨关节外科，上海200001
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 通讯作者: 岳冰，电子信箱：advbmp2@163.com。
  • 作者简介:?李晖（1993—），男，硕士生；电子信箱：jiayou1101@163.com
  • 基金资助:

    上海市教育委员会高峰高原学科建设计划（20161423）；国家自然科学基金（81472119，81672196）

Different patterns of titanium surface nanocrystallization and drug load aimed at establishing orthopedic implants with antimicrobial property

LI Hui, NIE Bin-en, YUE Bing   

  1. Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

     Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Grant Support, 20161423; National Natural Science Foundation of China, 81472119, 81672196

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摘要：

 钛及其合金因其良好的机械性能及生物惰性在骨科植入物方面得到广泛的应用。钛合金表面纳米化是赋予其多种生物功能化 重要的方法。一方面钛表面纳米化可促进骨髓间充质干细胞成骨分化并获得一定的抗菌性能；另一方面钛纳米管作为一种良好的药物 载体可以通过装载抗菌剂来有效预防和治疗骨科植入物相关感染，同时还可通过对纳米管进行生物化学修饰改善纳米管载药性能和控 制药物释放，达到理想的抗菌性能。纳米管载药后的药物释放主要可以分为机械性释放和智能控释 2 种类型。前者的释放方式往往存 在单一性和不可控性等缺陷，后者的药物释放则呈现种类丰富、释放量可控和条件触发响应释放等优点。该文对钛表面纳米化载药及 优化载药条件进行综述，为构建抗感染骨科植入物提供新的策略。

关键词: 二氧化钛纳米管, 抗菌性能, 抗生素, 生物活性, 智能控释, 骨科植入物

Abstract:

Titanium and titanium alloys, which are bio-inert materials and have excellent mechanical properties, have broad applications in clinic.On the one hand, TiO2 nanotube can effectively enhance the osteogenic differentiation of bone marrow mesenchymal stem cells and have antimicrobial abilities in some extent; On the other hand, TiO2 nanotube, an outstanding drug-carrier, could effectively prevent and treat bone implant-related infection by loading antimicrobial agents. By means of modifying the nanotube coating, improving the efficiency of drug loading and ameliorating release profile, the ideal antimicrobial property could be achieved. Strategies for drug release can be divided into two approaches, namely mechanical release and intellectual release. Mechanical release could fortify the antibacterial ability of coating, but the unicity and uncontrollability of agents diluting need to be resolved. By contrast, intellectual agents release has the advantages of multiple drug species, controllable release volume and programmed trigger condition. This article reviews the current and potential methods of antibacterial substances loading and release from TiO2 nanotube, and expects to provide the orientation for future direction of controllable and intellectual nanotube drug release.

Key words:  TiO2 nanotube, antimicrobial properties, antibiotics, bioactivity, controlled release, orthopedic implant