上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (6): 699-.doi: 10.3969/j.issn.1674-8115.2018.06.021

• 综述 • 上一篇    下一篇

长链非编码RNA在眼内恶性肿瘤中的作用及其机制

付晓1，黄蕊1，范先群2，张赫2   

  1. 1. 上海交通大学医学院，上海 200025；2. 上海交通大学医学院附属第九人民医院眼科，上海200011
  • 出版日期:2018-06-28 发布日期:2018-07-03
  • 作者简介:付晓（1998—），女，本科生；电子信箱：fx_5157@163.com。
  • 基金资助:
    国家自然科学基金（31470157），上海市重点实验室资助项目（17DZ2260100）

Roles of long non-coding RNA in intraocular malignant tumor and its mechanisms

FU Xiao1, HUANG Rui1, FAN Xian-qun2, ZHANG He2   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Ophthalmology, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 31470157; Fund for Key Laboratory of Shanghai, 17DZ2260100

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摘要： 视网膜母细胞瘤（retinoblastoma，RB）是儿童早期最常见的眼内恶性肿瘤，不仅影响视力，还会危及生命。葡萄膜黑色素瘤（uveal melanoma，UM）则是成人中最常见的原发眼内恶性肿瘤，近半数患者会发生肿瘤转移，并且转移后平均存活率低。长链非编码RNA（long non-coding RNA，lncRNA）是长度大于200 nt的非编码RNA。lncRNA在多重水平上调控基因的表达以影响肿瘤的增殖、迁移和侵袭，有望成为眼内恶性肿瘤治疗的新靶点。该文综述lncRNA在RB和UM等眼内恶性肿瘤发生发展中的作用及其机制。

关键词: 长链非编码RNA, 视网膜母细胞瘤, 葡萄膜黑色素瘤, 作用机制

Abstract:

Retinoblastoma (RB) is the most common intraocular malignant tumor in early childhood, which has an adverse effect not only on the eyesight, but also on patients’ life. Uveal melanoma (UM) is an another common intraocular malignant tumor in adults, nearly half of the patients will have metastasis of tumor with a low survival rate. The long non-coding RNAs (lncRNAs) are non-coding RNA with a length greater than 200 nt. More and more studies have confirmed that lncRNAs are involved in the proliferation, migration and invasion of tumorsregulating the gene at various levels, which makes lncRNAs become the novel target in the therapy of intraocular malignant tumors. This article reviewed studies of the roles and mechanisms of lncRNAs in RB and UM.

Key words: long non-coding RNA, retinoblastoma, uveal melanoma, mechanism

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