上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (7): 835-.doi: 10.3969/j.issn.1674-8115.2018.07.023

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TRIM28在肿瘤发生及胚胎发育中的作用

刘晔，王尹瑜，许晶晶，黄荷凤   

  1. 1. 上海交通大学医学院附属国际和平妇幼保健院胚胎源性疾病研究所，上海200030；2. 浙江大学医学院生殖遗传教育部重点实验室，杭州
  • 出版日期:2018-07-28 发布日期:2018-07-30
  • 通讯作者: 黄荷凤，电子信箱：huanghefg@sjtu.edu.cn。
  • 作者简介:刘晔（1990—），女，博士生；电子信箱：liuye90s@sjtu.edu.cn。
  • 基金资助:
    上海交通大学医学院博士创新基金(BXJ201640)

Roles of TRIM28 in tumorigenesis and embryogenesis

LIU Ye, WANG Yin-yu, XU Jing-jing, HUANG He-feng   

  1. 1. Institute of Embryo-Fetal Original Adult Disease, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. The Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou 310058, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    Doctoral Innovation Fund of Shanghai Jiao Tong University School of Medicine, BXJ201640

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摘要： TRIM28是一个包含多个结构域的大分子蛋白，属于人类三聚体蛋白家族中的一员。该家族共计包含60余种蛋白，以存在4个保守结构域即RING指、B-box 1型和2型以及亮氨酸卷曲螺旋结构为主要特征。TRIM28主要与含KRAB结构域（Kruppelassociated box domain）的转录因子相互作用，从而发挥转录共激活或共抑制作用，并在肿瘤发生、细胞分化、胚胎发育的调控中发挥重要作用。

关键词: 转录调节, 共激活子, 共抑制子, 肿瘤, 表观遗传, 甲基化

Abstract:

TRIM28, known as a kind of macro-molecules, consists of multiple domains and belongs to one of human tripartite motif-containing proteins families. This superfamily contains more than 60 proteins in total and is characterizedfour conservative domains, also referred to the RBCC domain, which is a RING (really interesting new gene) finger, two B-boxes (type 1 and type 2) and a leucine zipper coiled-coil region. TRIM28 plays its pivotal roles in transcriptional co-activation or co-repressioninteracting directly with transcription factors, within which is a Kruppel-associated box domain (KRAB domain). Moreover, itis critical during the development of embryos, thedifferentiation of cells and the regulation of cancers.

Key words: transcriptional regulation, co-activator, co-repressor, cancer, epigenetics, methylation

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