上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (2): 198-.doi: 10.3969/j.issn.1674-8115.2019.02.017

• 综述 • 上一篇    下一篇

长链非编码 RNA在中枢神经系统及精神分裂症中作用的研究进展

方钰，王卫娣，程影，崔东红   

  1. 上海交通大学医学院附属第九人民医院牙周病科，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室 /上海市口腔医学研究所，上海 200011
  • 出版日期:2019-02-28 发布日期:2019-03-19
  • 通讯作者: 崔东红，电子信箱：manyucc@126.com。
  • 作者简介:方钰（1994—），女，硕士生；电子信箱： FangYu@sjtu.edu.cn。
  • 基金资助:
    国家重点研发计划精准医学研究重点专项（ 2017YFC0909200）；国家自然科学基金（ 81671336）；上海市科学技术委员会科研计划项目（13dz2260500）

Research progress on the role of long non-coding RNAs in central nervous system and schizophrenia

FANG Yu, WANG Wei-di, CHENG Ying, CUI Dong-hong   

  1. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-02-28 Published:2019-03-19
  • Supported by:
    National Key Research and Development Program, 2017YFC0909200; National Natural Science Foundation of China, 81671336; Shanghai Committee of Science and Technology Research Project, 13dz2260500

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摘要： 精神分裂症是一种遗传度高达 80%的复杂重性精神疾病，有关其遗传成分的确切性质、功能以及遗传机制目前尚不清楚。长链非编码 RNA（long non-coding RNA，lncRNA）是在机体中广泛表达的一种转录本，其可通过多种方式调控基因的表达，参与神经细胞的增殖分化及突触的可塑性等生物学过程。近年来，诸多研究表明 lncRNA在精神分裂症患者和小鼠模型中均表达异常，参与疾病的发生与发展。该文就 lncRNA的生物学特征和基因调控机制以及 lncRNA在中枢神经系统和精神分裂症中的作用进行综述。

关键词: 长链非编码 RNA, 中枢神经系统, 精神分裂症, Gomafu, 精神分裂症断裂基因 2, 胚腹前脑 -2

Abstract:

Schizophrenia is a complex and severe psychiatric disorder with an estimated heritability of around 80%, but the exact nature and function of genetic components, and genetic mechanisms have not yet been revealed. Long non-coding RNAs (lncRNAs) are a type of non-coding RNAs which are widely expressed in the central nervous system. They regulate gene transcription in various ways, and participate in neural stem cell proliferation and differentiation, and synaptic plasticity. In recent years, many studies have reported that lncRNAs were abnormally expressed in patients with schizophrenia and momodels, which played an important role in this disorder. This review described the biological characteristics and gene regulation mechanisms of lncRNAs, and the role of lncRNAs in the central nervous system and the pathogenesis of schizophrenia.

Key words: long non-coding RNA (lncRNA), central nervous system, schizophrenia, Gomafu, disrupted in schizophrenia 2 (DISC2), embryonic ventral forebrain-2 (EVF-2)

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