上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (3): 282-.doi: 10.3969/j.issn.1674-8115.2019.03.011

• 论著·临床研究 • 上一篇    下一篇

小脑蚓部的 θ短阵快速脉冲模式重复经颅磁刺激对精神分裂症患者认知功能的影响

朱丽娜 1，张琼 2，蔡军 1，张伟波 1，朱红霞 1   

  1. 1. 上海交通大学医学院附属精神卫生中心，上海 200030; 2. 同济大学附属同济医院，上海 200065
  • 出版日期:2019-03-28 发布日期:2019-04-28
  • 通讯作者: 蔡军，电子信箱：caijun533@163.com。
  • 作者简介:朱丽娜（1994—），女，硕士生；电子信箱： zhulinapsy@163.com。
  • 基金资助:
    第四轮上海市公共卫生体系建设三年行动计划项目（ GWIV-6）；上海卫生计生系统重要薄弱学科建设项目（ 2015ZB0405）；上海市卫生和计划生育委员会科研课题青年项目（20164Y0100）

Effect of cerebellar vermal repetitive transcranial magnetic stimulation with theta burst stimulation paradigm on cognitive functions of patients with schizophrenia

ZHU Li-na1, ZHANG Qiong2, CAI Jun1, ZHANG Wei-bo1, ZHU Hong-xia1   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Tongji Hospital, Tongji University, Shanghai 200065, China
  • Online:2019-03-28 Published:2019-04-28
  • Supported by:
    The Fourth Round Public Health 3-Year Action Plan in Shanghai, GWIV-6; Key Developing Disciplines of Shanghai Municipal Commission of Health and Family Planning, 2015ZB0405; Research Project of Shanghai Municipal Commission of Health and Family Planning, 20164Y0100)。

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摘要： 目的 ·探索小脑蚓部的 θ短阵快速脉冲（ theta burst stimulation，TBS）模式重复经颅磁刺激（ repetitive transcranial magnetic stimulation，rTMS）对精神分裂症患者认知功能的疗效。方法 ·根据随机数字表法将 31例精神分裂症患者随机分为研究组与对照组，研究组 14例接受真刺激干预联合药物治疗，对照组 17例接受伪刺激干预联合药物治疗，为期 2周，共 10次。采用 MATRICS 公认认知成套测验（ MATRICS consensus cognitive battery，MCCB）在基线期、干预结束后、干预结束后 12周及干预结束后 24周进行评估。结果 ·基线期，研究组和对照组在 MCCB的各个因子得分及总体综合分数上差异均无统计学意义（ P>0.05）。干预后，经重复测量方差分析，社会认知因子得分的时间主效应具有统计学意义（ F3.901，P<0.05），但组别主效应、时间与组别的交互效应无统计学意义（ P>0.05）；信息处理速度、注意 /警觉性、工作记忆、词语学习、视觉学习、推理和问题解决因子得分及总体综合分数的组别主效应、时间主效应、时间与组别的交互效应均不具有统计学意义（ P>0.05）。结论 ·小脑蚓部的 TBS模式 rTMS干预未能改善精神分裂症患者的信息处理速度、注意 /警觉性、工作记忆、词语学习、视觉学习、推理和问题解决以及社会认知能力。

关键词: 重复经颅磁刺激, &, theta, 短阵快速脉冲模式, 精神分裂症, 认知功能

Abstract:

Objective · To explore the effect of cerebellar vermal repetitive transcranial magnetic stimulation (rTMS) with theta burst stimulation (TBS) paradigm on cognitive functions of patients with schizophrenia. Methods · Thirty-one schizophrenia patients were randomly assigned into study group (n14) and control group (n17). Patients in the study group received a combination of rTMS and drug therapy, and patients in the control group received a combination of sham rTMS and drug therapy. The intervention lasted for 2 weeks, a total of 10 times. To evaluate the effect of rTMS on cognitive functions, MATRICS consensus cognitive battery (MCCB) was used to assess at baseline, after the intervention, 12 weeks and 24 weeks after the end of the intervention. Results · At baseline, there were no significant differences between two groups in the scores of each factor and the overall composite scores (P>0.05). After the intervention, repeated measures analysis of variance showed that the main effect of time was statistically significant in the scores of social cognitive (F3.901, P<0.05). However, the main effect of group and the interaction between time and group showed no significance in the scores of the factor (P>0.05). Moreover, in the scores of speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving and the overall composite scores, the main effect of group/time and the interaction between time and group were not significant (P>0.05). Conclusion · Application of TBS rTMS to cerebellar vermal is not superior compared with sham rTMS in improving the above seven cognitive domains.

Key words: repetitive transcranial magnetic stimulation, theta burst stimulation, schizophrenia, cognitive function

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