上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (06): 719-727.doi: 10.3969/j.issn.1674-8115.2020.06.004

• 创新团队成果专栏 • 上一篇    下一篇

冰冻胚胎移植子代幼儿的体格和神经认知发育评估

董则含*，吴琰婷*，刘 含，王尹瑜，黄荷凤   

  1. 上海交通大学医学院附属国际和平妇幼保健院辅助生殖科，上海胚胎源性疾病重点实验室，上海 200030
  • 出版日期:2020-06-28 发布日期:2020-06-28
  • 通讯作者: 黄荷凤，电子信箱：huanghefg@hotmail.com。
  • 作者简介:董则含（1992—），女，硕士生；电子信箱：dzhyixue@163.com。吴琰婷（1981—），女，博士；电子信箱：yanting_wu@163.com。
  • 基金资助:
    国家重点研发计划（2016YFC1000203）；国家自然科学基金（81661128010）；上海市卫生健康委员会基金（201840210）；上海申康医院发展中心临床研究培育项目（SHDC12018X17）；上海交通大学医学院高水平地方高校创新团队（SSMU-ZLCX20180400）。

Evaluation of physical and neurocognitive development of infants conceived from frozen embryo transfer

DONG Ze-han*, WU Yan-ting*, LIU Han, WANG Yin-yu, HUANG He-feng   

  1. Shanghai Key Laboratory of Embryo Original Diseases, Department of Assisted Reproduction, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-06-28 Published:2020-06-28
  • Supported by:
    National Key R&D Program of China (2016YFC1000203); National Natural Science Foundation of China (81661128010); Project of Shanghai Municipal Health Commission (201840210); Project of Shanghai Shenkang Hospital Development Center (SHDC12018X17); Innovative Research Team of High-level Local Universities in Shanghai (SSMU-ZLCX20180400).

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摘要： 目的·评估冰冻胚胎移植（frozen embryo transfer，FET）子代幼儿的体格和神经认知发育情况。方法·招募248例经FET和自然受孕（natural conception，NC）的单胎子代幼儿（1.5～4 岁）作为FET子代随访队列，随访并评估幼儿的体格及神经认知发育。利用多元Logistic回归分析评估FET子代认知迟缓的潜在风险。结果·FET组与NC对照组幼儿的身高、体质量和体质量指数的Z评分构成比间差异无统计学意义。多元Logistic回归分析显示，与NC对照组相比，FET组幼儿的神经认知发育异常和迟缓的风险较高，尤其在精细运动（OR=3.01，95%CI 1.48～6.11）和社交能力发育方面（OR=3.76，95%CI 1.63～8.69）；且在FET组中，女童的社交能力发育风险高于男童。结论·FET对子代幼儿早期的神经认知发育可能有不良影响。

关键词: 冰冻胚胎移植, 体外受精, 体格发育, 神经认知发育

Abstract:

Objective · To evaluate the physical and neurocognitive development of infants conceived from frozen embryo transfer (FET). Methods · Two hundred and forty-eight infants (1.5-4 years old) conceived from FET and natural conception (NC) were recruited as the follow-up cohort of FET offspring, and their physical and neurocognitive development were followed up and evaluated. Multiple Logistic regression analysis was used to assess the potential risk of cognitive retardation in FET offspring. Results · There was no significant difference in composition ratio of Z score for height, weight and body mass index between the FET group and the NC control group. Multiple Logistic regression analysis showed that compared with the NC control group, the risk of neurocognitive development abnormalities and retardation was higher in the FET group, especially in fine motor (OR=3.01, 95%CI 1.48-6.11) and social development domains (OR=3.76, 95%CI 1.63-8.69); and in the FET group, the social development risk of female infants was higher than that of male infants. Conclusion · FET may exert a negative impact on the early neurocognitive development of infants.

Key words: frozen embryo transfer (FET), in vitro fertilization (IVF), physical growth, neurocognitive development

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