上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (07): 968-973.doi: 10.3969/j.issn.1674-8115.2020.07.017

• 综述 • 上一篇    下一篇

具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤的临床研究进展

曾 素，许培培，郭明高   

  1. 上海交通大学附属第六人民医院普外科，上海 200233
  • 出版日期:2020-07-28 发布日期:2020-09-23
  • 通讯作者: 郭明高，电子信箱：guominggao203@163.com。
  • 作者简介:曾 素（1996—），女，硕士生；电子信箱：zengsucela@163.com。
  • 基金资助:
    国家自然科学基金（81672373）。

Clinical progress of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

ZENG Su, XU Pei-pei, GUO Ming-gao   

  1. Department of Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233
  • Online:2020-07-28 Published:2020-09-23
  • Supported by:
    National Natural Science Foundation of China (81672373).

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摘要： 2015年美国和加拿大病理学会经研究讨论后首次将非浸润性包裹性滤泡型甲状腺乳头状癌改名为具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤（noninvasive follicular thyroid neoplasm with papillary-like nuclear features，NIFTP）。2017年，世界卫生组织内分泌肿瘤分类将该类型肿瘤的命名收录其中，NIFTP指具有包裹性或边界清楚、伴滤泡性生长模式和甲状腺乳头状核特征的非浸润性甲状腺肿瘤。超声、细胞学检查和基因检测在一定程度上有助于NIFTP的诊断，但难以与浸润性包裹性滤泡型甲状腺乳头状癌相鉴别。该文主要对NIFTP的临床特征、诊治特点及预后的最新进展进行综述。

关键词: 具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤, 滤泡型甲状腺乳头状癌, 临床特征, 诊断

Abstract:

In 2015, the United States and Canadian Academy of Pathology re-evaluated noninvasive encapsulated follicular variant of papillary thyroid carcinomas (NI-EFVPC), and then the new terminology of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was initially introduced to replace NI-EFVPTC. In 2017, the World Health Organization also used NIFTP in the endocrine tumor classification. NIFTP is an encapsulated or clearly delimited noninvasive neoplasm with a follicular growth pattern and nuclear features of papillary thyroid carcinoma. Ultrasonography, cytology examination and genetic test are helpful to identify NIFTP, but the results overlap with invasive encapsulated follicular variant of papillary thyroid carcinoma. This paper mainly reviews the latest research in the clinical features, diagnosis and treatment features and prognosis of NIFTP.

Key words: noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), follicular variant of papillary thyroid carcinoma (FVPTC), clinical feature, diagnosis

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