上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (09): 1302-1307.doi: 10.3969/j.issn.1674-8115.2020.09.022

• 综述 • 上一篇    下一篇

多系统萎缩生物标志物的研究进展

朱 琳，刘 军   

  1. 上海交通大学医学院附属瑞金医院神经内科，上海200025
  • 出版日期:2020-09-28 发布日期:2020-11-04
  • 通讯作者: 刘 军，电子信箱：jly0520@hotmail.com。
  • 作者简介:朱 琳（1995—），女，博士生；电子信箱：zhulin950301@163.com。
  • 基金资助:
    上海市教育委员会高峰高原学科建设计划（20152201）。

Progress in biomarkers of multiple system atrophy

ZHU Lin, LIU Jun   

  1. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20152201).

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摘要： 多系统萎缩是以自主神经、锥体外系、锥体束等多系统受累为特点的一种帕金森综合征，对左旋多巴反应不佳。该病临床诊断难度大，多数生物标志物特异度和敏感度均不高。因此，有研究建议将多项指标结合应用以提高诊断的准确度。除体液中的生物化学标志物外，影像学、病理学等生物标志物的相关研究也取得了一定进展。该文综述近年来多系统萎缩生物标志物的研究进展，包括血液和脑脊液中的蛋白和miRNA，以及影像学特征和外周组织中的α-突触核蛋白沉积。

关键词: 多系统萎缩, 生物标志物, 神经影像

Abstract:

Multiple system atrophy is a neurodegenerative disease, which is characterized by a combination of autonomic failure, Parkinsonian features, pyramidal and cerebellar dysfunction, and is poorly reactive to levodopa. Few biomarkers with high sensitivity or specificity have been applicable in the diagnosis of multiple system atrophy, making it a challenge to correctly diagnose this disease. Therefore, some researches combined several biomarkers to improve the diagnosis accuracy. Apart from those in body fluid, progress has been made in new biomarkers of neuroimaging and pathology. In this review, the advances in the identification of biomarkers of multiple system atrophy are summarized, and some candidate biomarkers that worth more investigation, including proteins and miRNAs in blood or cerebrospinal fluid, parameters in molecular and functional imaging, and pathologic features of peripheral tissue are described .

Key words: multiple system atrophy (MSA), biomarker, neuroimaging

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