上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2020, Vol. 40 ›› Issue (12): 1656-1659.doi: 10.3969/j.issn.1674-8115.2020.12.016

• 综述 • 上一篇    下一篇

抗精神病药物诱发代谢综合征的DNA甲基化研究进展

项思莹，李宁宁，徐一峰#，陈剑华#   

  1. 上海交通大学医学院附属精神卫生中心，上海市精神心理疾病临床医学研究中心，上海200030
  • 出版日期:2020-12-28 发布日期:2021-02-02
  • 通讯作者: 陈剑华，电子信箱：jianhua.chen@smhc.org.cn。徐一峰，电子信箱：xuyifeng@smhc.org.cn。#为共同通信作者。
  • 作者简介:项思莹（1994—），女，硕士生；电子信箱：xiangsiying@sjtu.edu.cn。
  • 基金资助:
    国家重点研发计划（2016YFC1306900）；国家自然科学基金（81871051，82071500）；上海市精神心理疾病临床医学研究中心项目（19MC1911100）；上海市重性精神病重点实验室项目（13dz2260500）；上海申康医院发展中心临床科技创新项目（SHDC12017X12）；上海市青年拔尖人才支持计划；上海市精神卫生中心临床研究中心项目（CRC2018DSJ01-4）。

Advances in DNA methylation mechanism of antipsychotic-induced metabolic syndrome

XIANG Si-ying, LI Ning-ning, XU Yi-feng#, CHEN Jian-hua#   

  1. Shanghai Clinical Research Center for Mental Health, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    National Key Research and Development Program (2016YFC1306900); National Natural Science Foundation of China (81871051, 82071500); Project of Shanghai Clinical Research Center for Mental Health (19MC1911100); Project of Shanghai Key Laboratory of Psychotic Disorders (13dz2260500); Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center (SHDC12017X12); Shanghai Youth Top-notch Talent Support Program； Research Project of Shanghai Mental Health Center (CRC2018DSJ01-4).

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摘要： 精神分裂症患者更易合并代谢综合征，其发生和发展可能与基因和环境相互作用有关。抗精神病药物是精神分裂症主要治疗手段，会引起相关基因DNA甲基化的改变，进而影响药物疗效或产生代谢不良反应。该文就DNA甲基化与精神分裂症合并代谢综合征之间的关系进行综述。

关键词: 抗精神病药物, 精神分裂症, 代谢综合征, DNA甲基化

Abstract:

Schizophrenia patients are more likely to develop metabolic syndrome which is related to the interactions between gene and environment. Antipsychotic drugs, the main treatments, can change the DNA methylation level of related genes and then influence the efficacy and adverse effects of drugs. This article reviews the relationship between DNA methylation and schizophrenia with metabolic syndrome.

Key words: antipsychotic drug, schizophrenia, metabolic syndrome, DNA methylation

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