肠道菌群及其代谢产物与妊娠期糖尿病相关性的研究进展

doi:10.3969/j.issn.1674-8115.2023.05.016

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (5): 641-647.doi: 10.3969/j.issn.1674-8115.2023.05.016

• 综述 • 上一篇

肠道菌群及其代谢产物与妊娠期糖尿病相关性的研究进展

刘芊若¹^,²(), 方子晨¹^,², 吴宇涵³, 钟羡欣⁴, 国沐禾¹^,², 贾洁¹^,²^,⁵()

^1.上海交通大学医学院附属新华医院临床营养科，上海 200092
^2.上海交通大学医学院医学技术学院临床营养系，上海 200025
^3.上海交通大学医学院儿科学院，上海 200025
^4.上海交通大学医学院附属第九人民医院临床医学院，上海 200011
^5.上海交通大学医学院附属新华医院，上海市小儿消化与营养重点实验室，上海 200092

收稿日期:2022-12-12 接受日期:2023-02-21 出版日期:2023-05-28 发布日期:2023-07-11
通讯作者: 贾洁 E-mail:kinnal@163.com;jia@shsmu.edu.cn
作者简介:刘芊若（2001—），女，本科生；电子信箱：kinnal@163.com。
基金资助:
国家自然科学基金(81501338);上海交通大学医学院大学生创新训练计划(S202210248311)

Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus

LIU Qianruo¹^,²(), FANG Zichen¹^,², WU Yuhan³, ZHONG Xianxin⁴, GUO Muhe¹^,², JIA Jie¹^,²^,⁵()

^1.Department of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
^2.Department of Clinical Nutrition, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^3.School of Pediatrics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
^4.College of Clinical Medicine, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
^5.Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Received:2022-12-12 Accepted:2023-02-21 Online:2023-05-28 Published:2023-07-11
Contact: JIA Jie E-mail:kinnal@163.com;jia@shsmu.edu.cn
Supported by:
National Natural Science Foundation of China(81501338);Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine(S202210248311)

摘要/Abstract

摘要：

近年来，妊娠期糖尿病（gestational diabetes mellitus，GDM）在全球的发病率持续攀升。研究显示，GDM可增加孕妇不良妊娠结局的发生风险，并导致恶性代际循环。该疾病成因复杂且发病机制尚未被完全阐明，孕期膳食评估和指导是目前临床上管理GDM的一线方法。孕期合理饮食对肠道菌群及其代谢产物有重要作用，而肠道菌群功能的紊乱则与代谢性疾病的发生密切相关。已有研究显示，短链脂肪酸、氧化三甲胺、胆汁酸等肠道菌群代谢产物可受到饮食的强烈影响，并在与胰岛素抵抗相关的代谢紊乱（如GDM）中发挥重要作用。目前，医学营养疗法改善肠道菌群以防治代谢性疾病取得了一定进展，这为控制GDM提供了新的方向。该文针对GDM的现状、GDM孕妇肠道菌群的变化特征、GDM相关肠道菌群代谢产物、调控肠道菌群及其代谢产物防治GDM的方式进行综述。

关键词: 妊娠期糖尿病, 肠道菌群, 肠道菌群代谢产物, 膳食评估

Abstract:

The global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation. The etiology of GDM is complex and the pathogenesis has not been fully elucidated. Maternal dietary assessment and guidance is the first-line method for managing GDM in clinical practice. Reasonable diet plays an important role in gut microbia and its metabolites during pregnancy, and the dysfunction of gut microbia is closely related to the occurrence of metabolic diseases. It has been shown that gut microbial metabolites such as short-chain fatty acids (SCFAs), trimethylamine oxide (TMAO) and bile acids are strongly influenced by diet and play an important role in metabolic disorders related to insulin resistance (such as GDM). Progress has been made in the prevention and treatment of metabolic diseases by improving gut microbia through medical nutrition therapy, which provides a new direction for the control of GDM. The status quo of GDM, the characteristics and alteration of gut microbia in pregnant women with GDM, the GDM-related gut microbial metabolites, and the feasible prevention and treatment of GDM by targeting gut microbia and its metabolites are reviewed.

Key words: gestational diabetes mellitus (GDM), gut microbia, gut microbia metabolite, dietary estimation

中图分类号:

R714.2

刘芊若, 方子晨, 吴宇涵, 钟羡欣, 国沐禾, 贾洁. 肠道菌群及其代谢产物与妊娠期糖尿病相关性的研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(5): 641-647.

LIU Qianruo, FANG Zichen, WU Yuhan, ZHONG Xianxin, GUO Muhe, JIA Jie. Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(5): 641-647.

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肠道菌群及其代谢产物与妊娠期糖尿病相关性的研究进展

Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus

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