神经调控技术在帕金森病治疗中的应用研究进展

doi:10.3969/j.issn.1674-8115.2024.02.012

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (2): 258-263.doi: 10.3969/j.issn.1674-8115.2024.02.012

• 综述 • 上一篇

神经调控技术在帕金森病治疗中的应用研究进展

胡灿芳¹^,²(), 钟传钰³, 曹立¹()

^1.上海交通大学医学院附属第六人民医院神经内科，上海 200233
^2.上海市第六人民医院金山分院神经内科，上海 201599
^3.上海交通大学医学院附属第六人民医院超声医学科，上海 200233

收稿日期:2022-12-02 接受日期:2024-01-02 出版日期:2024-02-28 发布日期:2024-03-25
通讯作者: 曹立 E-mail:tian2008shi2004@163.com;caoli2000@yeah.net
作者简介:胡灿芳（1986—），女，主治医师，硕士生；电子信箱：tian2008shi2004@163.com。
基金资助:
“科技创新行动计划”医学创新研究专项重点项目(21Y21901100);上海申康医院发展中心医企融合创新成果转化专项(SHDC2022CRD037)

Research progress of neuromodulation in the treatment of Parkinson's disease

HU Canfang¹^,²(), ZHONG Chuanyu³, CAO Li¹()

^1.Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
^2.Department of Neurology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai 201599, China
^3.Department of Ultrasound Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China

Received:2022-12-02 Accepted:2024-01-02 Online:2024-02-28 Published:2024-03-25
Contact: CAO Li E-mail:tian2008shi2004@163.com;caoli2000@yeah.net
Supported by:
“Science and Technology Innovation Action Plan” of Medical Innovation Research Major Project(21Y21901100);Medicine-industry Integration Innovation Product Translation Project of Shanghai Hospital Development Center(SHDC2022CRD037)

摘要/Abstract

摘要：

帕金森病（Parkinson's disease，PD）是一种常见的神经系统退行性疾病，以静止性震颤、运动迟缓、肌强直、姿势异常为主要临床特征。多巴胺能药物是治疗PD的主要药物，但长期使用会使患者出现药效减退，甚至发生异动症、“开-关”现象等不良反应。神经调控技术是一种通过电能、磁场、超声等方式来兴奋或抑制大脑神经元活动、调节神经可塑性变化，从而达到治疗、改善疾病的生物医学工程技术。在PD的非药物治疗方面，神经调控技术作为一类新型的治疗手段，显示出了良好的疗效并具有不良反应少、易耐受等优点。基于此，该文针对脑深部电刺激、经颅磁刺激、经颅直流电刺激、经颅聚焦超声等常见神经调控技术在PD治疗中的应用研究进展进行综述。

关键词: 神经调控技术, 帕金森病, 脑深部电刺激, 经颅磁刺激, 经颅直流电刺激, 经颅聚焦超声

Abstract:

Parkinson's disease (PD) is a common degenerative neurological disorder, characterized by static tremor, bradykinesia, myotonia and postural abnormalities. Dopaminergic drugs are the main drugs in the treatment of PD, but long-term use will lead to drug efficacy loss, and even cause some adverse reactions such as dyskinesia and "on-off" phenomenon. Neuromodulation is a kind of biomedical engineering technology that can stimulate or inhibit the activity of brain neurons and regulate the changes of neuroplasticity by means of electric energy, magnetic field, ultrasound and other methods, so as to achieve treatment and improvement of diseases. In the non-drug treatment of PD, neuromodulation, as a new therapeutic means, has shown good efficacy, and has the advantages of small adverse reactions and easy tolerance. Based on this, this article reviews the research progress of several common neuromodulation in PD, including deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation and transcranial focused ultrasound.

Key words: neuromodulation, Parkinson's disease (PD), deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial focused ultrasound (tFUS)

中图分类号:

R741.05

胡灿芳, 钟传钰, 曹立. 神经调控技术在帕金森病治疗中的应用研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(2): 258-263.

HU Canfang, ZHONG Chuanyu, CAO Li. Research progress of neuromodulation in the treatment of Parkinson's disease[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(2): 258-263.

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神经调控技术在帕金森病治疗中的应用研究进展

Research progress of neuromodulation in the treatment of Parkinson's disease

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