上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (9): 1077-.

• 论著（临床研究） • 上一篇    下一篇

血栓素A2含量与脑梗死的相关性分析

朱玉萍, 傅 毅, 刘桂冬, 陈生弟   

  1. 上海交通大学 医学院瑞金医院神经内科 神经病学研究所, 上海 200025
  • 出版日期:2009-09-25 发布日期:2009-09-29
  • 作者简介:朱玉萍（1981—）, 女, 硕士生；电子信箱: lvwazi@yahoo.com.cn。
  • 基金资助:

    上海市科委基金（03DZ19702）

Correlation of serum thromboxane A2 and cerebral infarction

ZHU Yu-ping, FU Yi, LIU Gui-dong, CHEN Sheng-di   

  1. Department of Neurology, Institute of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2009-09-25 Published:2009-09-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 03DZ19702

PDF (PC)

1667

摘要：

目的 探讨血清中血栓素A2 (TXA2)含量与脑梗死的关系。方法 测定72例脑梗死患者和39名正常对照者血清中TXA2含量；对脑梗死患者进行美国国立卫生研究院卒中量表（NHISS）评分，评估其脑梗死严重程度。结果 脑梗死患者血清中TXA2含量明显高于正常对照组（P=0.00）。血清TXA2含量是脑梗死的独立危险因素（P=0.000）。直线回归分析显示，脑梗死患者的血清TXA2含量与NHISS评分呈正相关（r=0.753, P=0.000）；多元线性回归分析显示，血糖对血清中TXA2的含量有显著影响(P=0.002)。结论 血清TXA2是脑梗死的独立危险因素，并与脑梗死病情严重程度呈正相关；脑梗死患者血清TXA2含量的升高可能与血糖增高有关。

关键词: 血栓素A2, 脑梗死, 血糖

Abstract:

Objective To investigate the relationship between serum thromboxane A2 (TXA2) and cerebral infarction. Methods Serum TXA2 contents of 72 patients with cerebral infarction and 39 normal controls were measured. The severity of symptoms and signs in 72 patients were evaluated by NIH Stroke Scale (NHISS). Results Serum TXA2 contents were significantly higher in cerebral infarction than those in controls (P=0.00). Serum TXA2 was an independent risk factor for cerebral infarction (P=0.000). Linear regression analysis showed that there was a positive correlation between serum TXA2 and NHISS in cerebral infarction (r=0.753, P=0.000). Multiple linear regression analysis indicated that serum glucose had significant effect on serum TXA2 (P=0.002). Conclusion Serum TXA2 is an independent risk factor for cerebral infarction, and there is a positive correlation between serum TXA2 and severity of cerebral infarction. Increased serum TXA2 in cerebral infarction may be associated with increased serum glucose.

Key words: thromboxane A2, cerebral infarction, serum glucose

中图分类号: