上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (10): 1256-.

• 综述 • 上一篇    下一篇

表观遗传调节与常见疾病的发生

高艳虹1, 综述；李定国2, 吴超群3, 审校   

  1. 上海交通大学 医学院新华医院 1. 老年医学科, 2. 消化内科, 上海 200092；3. 复旦大学 生命科学院遗传学研究所, 上海 200011
  • 出版日期:2009-10-25 发布日期:2009-10-26
  • 作者简介:高艳虹（1972—）, 女, 副主任医师, 博士；电子信箱: jzh429@yahoo.com.cn。

Epigenetic regulation and human common diseases

GAO Yan-hong1, reviewer；LI Ding-guo2, WU Chao-qun3, reviser   

  1. 1. Department of Geriatrics, 2. Department of Gastroenterology, Xinhua Hospital,School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China；3. Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China
  • Online:2009-10-25 Published:2009-10-26

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摘要：

近年来发现一些表观遗传调节方式以及表观遗传特征变化与多种疾病相关。表观遗传机制的失调将影响染色质结构和基因表达，导致复杂的综合征、多因素疾病及癌症。文章就几种常见疾病的表观遗传机制研究进展作一综述。

关键词: 表观遗传, 癌症, 心血管病, 代谢综合征, 自身免疫病

Abstract:

In the past few years, it has been disclosed that identified epigenetic processes and epigenetic changes are involved in human diseases. Disorders of these processes may influence chromatin structure and gene expression, which may result in complicated syndroms, multiple-factor diseases and cancers. The research progress of epigenetic processes of several diseases is reviewed in this paper.

Key words: epigenetics, cancer, angiocardiopathy, metabolism syndrom, autoimmune diseases

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