上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (4): 463-.

• 综述 • 上一篇    下一篇

Notch信号通路与心脏发育和组织再生

陈 浩, 综述；徐志伟, 审校   

  1. 上海交通大学医学院 上海儿童医学中心心胸外科, 上海 200127
  • 出版日期:2010-04-25 发布日期:2010-04-26
  • 作者简介:陈 浩（1978—）, 男, 主治医师, 博士生；电子信箱: chenhaoo@hotmail.com。
  • 基金资助:

    国家自然科学基金(30772143)

Notch signaling pathway in cardiomyogenesis and regeneration

CHEN Hao, reviewer；XU Zhi-wei, reviser   

  1. Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
  • Online:2010-04-25 Published:2010-04-26
  • Supported by:

    National Natural Science Foundation of China, 30772143

PDF (PC)

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摘要：

Notch信号通路参与细胞增生、分化和凋亡等诸多过程。Notch不仅在心血管系统发育中发挥重要作用，而且通过阻止心肌细胞过度肥大和维持干细胞池功能稳定，参与成体心脏的内稳态调节和心肌修复过程。文章就近年来有关Notch信号通路结构特点、调控胚胎期和出生后心脏发育、维持心脏结构完整性及应用于组织再生等方面的研究进展作一综述。

关键词: Notch, 心脏发育, 再生, 调控

Abstract:

Notch signaling pathway participates in extensive cellular processes such as cell proliferation, differentiation and apoptosis. Notch plays a crucial role in cardiovascular development. Furthermore, Notch could be important for cardiac homeostasis regulation and tissue renewal by protecting the heart from an excessive and detrimental hypertrophic response and controlling the maintenance of stem cell pools. The paper emphatically reviews the current knowledge of the versartility of Notch signaling in fetal and postnatal development and finally, discusses the impact on maintenance of cardiac integrity and the potential for regenerative therapies.

Key words: Notch, cardiomyogenesis, regeneration, regulation