上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (9): 1039-.doi: 10.3969/j.issn.1674-8115.2010.09.005

• 专题报道（影像医学与核医学） • 上一篇    下一篇

18F-FDG PET/CT寻找多发性骨转移瘤原发灶的临床应用价值

陈 刚, 张 淼, 胡佳佳, 江旭峰, 王 超, 李 彪   

  1. 上海交通大学 医学院附属瑞金医院核医学科, 上海 200025
  • 出版日期:2010-09-25 发布日期:2010-09-27
  • 通讯作者: 李 彪, 电子信箱:lb10363@rjh.com.cn。
  • 作者简介:陈 刚（1969—）, 男, 副主任医师, 学士；电子信箱: rjchengang@189.cn。
  • 基金资助:

    上海市重点学科建设项目(S30203)

Clinical application of 18F-FDG PET/CT in detection of primary tumors of multiple bone metastatic tumors

CHEN Gang, |ZHANG Miao, |HU Jia-jia, |JIANG Xu-feng, |WANG Chao, |LI Biao   

  1. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2010-09-25 Published:2010-09-27
  • Supported by:

    Shanghai Leading Academic Discipline Project, S30203

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摘要：

目的 探讨18F-FDG PET/CT寻找多发性骨转移瘤原发灶的临床应用价值。方法 回顾性分析77例多发性骨转移瘤患者行18F-FDG PET/CT寻找原发病灶的情况，并与病理结果进行对照。结果 在77例患者中，18F-FDG PET/CT发现原发灶的共有44例，其中40例（51.9%）经手术或活检病理证实为原发灶，另有4例为假阳性。未找到原发灶的37例多发性骨转移瘤中，1例术后经病理证实为胃印戒细胞癌，其余36例随访时仍未找到原发灶。18F-FDG PET/CT寻找多发性骨转移瘤原发灶的灵敏度为97.6%，特异度为88.9%，符合率为93.5%。结论 18F-FDG PET/CT寻找多发性骨转移瘤原发灶有一定的临床应用价值，对制定合适的治疗方案有积极作用。

关键词: 骨转移瘤, 原发灶, PET, 放射性核素显像

Abstract:

Objective To explore the clinical application of 18F-FDG PET/CT in detection of primary tumors of multiple bone metastatic tumors. Methods The results of detection of primary tumors by 18F-FDG PET/CT in 77 patients with multiple bone metastatic tumors were retrospectively analysed, and comparisons were conducted with pathological findings. Results In all the 77 patients, 18F-FDG PET/CT revealed 44 suspected primary tumors, among whom 40 were confirmed by surgical or pathological examinations, and the other 4 were false positive cases. In the 37 patients without primary tumors detected by 18F-FDG PET/CT, one was diagnosed as gastric Signet ring cell carcinoma by pathological examination after operation, and primary tumors were not found in the other 36 patients during the follow up. The sensitivity, specificity and accuracy of 18F-FDG PET/CT in detection of primary tumors were 97.6%, 88.9% and 93.5%, respectively. Conclusion 18F-FDG PET/CT has definite value in detection of primary tumors of multiple bone metastatic tumors.

Key words: bone metastatic tumor, primary tumor, PET, radionuclide imaging