上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (12): 1550-.doi: 10.3969/j.issn.1674-8115.2010.12.024

• 综述 • 上一篇    下一篇

microRNA-155与恶性肿瘤的关系

施琳俊, 周曾同, 蒋伟文   

  1. 上海交通大学 医学院附属第九人民医院口腔黏膜科 上海市口腔医学重点实验室, 上海 200011
  • 出版日期:2010-12-25 发布日期:2010-12-31
  • 通讯作者: 蒋伟文, 电子信箱: wwjiang33@hotmail.com。
  • 作者简介:施琳俊（1983—）, 男, 博士生；电子信箱: shi-linjun@hotmail.com。
  • 基金资助:

    国家自然科学基金（30872887）；上海市科委基金（08DZ2271100）；上海市重点学科建设项目（S30206）

Relationship between microRNA-155 and malignant tumors

SHI Lin-jun, ZHOU Zeng-tong, JIANG Wei-wen   

  1. Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2010-12-25 Published:2010-12-31
  • Supported by:

    National Natural Science Foundation of China, 30872887；Shanghai Science and Technology Committee Foundation, 08DZ2271100；Shanghai Key Discipline Construction Project, S30206

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摘要：

MicroRNA (miRNA)是一种非编码的短链RNA，它在转录后水平调节多个靶基因的表达，因此涉及一系列细胞发育过程的调控。miRNA是近年来生命科学研究的热点，研究表明其与恶性肿瘤的发生密切相关。MicroRNA-155（miRNA-155）来源于活化的淋巴细胞及单核/巨噬细胞内高表达的非编码转录产物，文章就miRNA-155与恶性肿瘤关系的研究进展进行综述。

关键词: microRNA, microRNA-155, 恶性肿瘤, 靶基因

Abstract:

MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally modulate the expression of multiple target genes and are thus implicated in a wide array of cellular and developmental processes. Recently miRNAs and their close associations with malignant tumors remain a major concern. Nowadays microRNA-155(miRNA-155) has been found to be involved in different types of malignant tumors. Here we summarize the research progress of relationship between miRNA-155 and its association with malignant tumors.

Key words: microRNA, microRNA-155, malignant tumor, target gene