上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (12): 1565-.doi: 10.3969/j.issn.1674-8115.2010.12.027

• 综述 • 上一篇    下一篇

成骨生长肽促成骨作用的研究进展

陈 晓, 罗贝尔, 苏佳灿   

  1. 第二军医大学附属长海医院骨科, 上海 200433
  • 出版日期:2010-12-25 发布日期:2010-12-31
  • 作者简介:陈 晓（1987—）, 男, 八年制临床医学博士生；电子信箱: sirchenxiao@126.com。

Research progress of osteogenic effects of osteogenic growth peptide

CHEN Xiao, LUO Bei-er, SU Jia-can   

  1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2010-12-25 Published:2010-12-31

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摘要：

成骨生长肽（OGP）具有促成骨作用，具有较大的潜在临床应用价值，是国内外研究的热点。动物体内实验和体外细胞实验表明，OGP能促进骨密度增加，加速骨折愈合，促进体外培养大鼠成骨细胞的成骨功能，增加核心结合因子α1、Ⅰ型胶原mRNA表达水平，促进骨髓间充质干细胞的增殖和分化，上调成骨标志物的表达。文章对OGP促成骨作用的研究进展进行综述。

关键词: 成骨生长肽, 成骨, 骨髓间充质干细胞

Abstract:

Osteogenic growth peptide (OGP), which bears osteogenic effects, possesses a great potential in clinical use, and has been the focus of intense investigation worldwide. Both animal experiments in vivo and cellular experiments in vitro have demonstrated that OGP can increase bone density, accelerate fracture healing, promote osteogenic functions of osteoblasts, up-regulate expression of core binding factor alpha 1 and type I collagen mRNA, and stimulate proliferation and differentiation of bone marrow mesenchymal stem cells, finally leading to osteogenesis. The research progress of osteogenetic effects of OGP is reviewed in this paper.

Key words: osteogenic growth peptide, osteogenesis, bone marrow mesenchymal stem cells