上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1643-.doi: 10.3969/j.issn.1674-8115.2011.11.030

• 综述 • 上一篇    下一篇

精神分裂症的DNA甲基化研究进展

张 晨, 易正辉, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 作者简介:张 晨（1977—）, 男, 主治医师, 博士；电子信箱: zhangchen645@gmail.com。
  • 基金资助:

    国家自然科学基金（30971047, 81000581）；国家高技术研究发展计划（“八六三”计划）(2006AA02Z430)；上海市自然科学基金（10ZR1425700）；上海市卫生局青年科研基金（2009Y051）；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）

Research progress of DNA methylation in schizophrenia

ZHANG Chen, YI Zheng-hui, FANG Yi-ru   

  1. Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971047, 81000581；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Natural Science Foundation, 10ZR1425700；Shanghai Municipal Health Bureau Foundation, 2009Y051；Shanghai Jiaotong University School of Medicine Foundation, 2008-6

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摘要：

环境因素在精神分裂症发生过程中具有重要作用。研究发现，环境因素可能通过DNA甲基化机制调控基因表达，导致精神分裂症的发生风险增加。文章就DNA甲基化对环境因素影响及其在精神分裂症发生中作用的相关研究进展作一综述。

关键词: DNA甲基化, 环境因素, 精神分裂症

Abstract:

Environmental factors play an important role in the etiology of schizophrenia. Recent studies have found that environmental factors may regulate gene expression though DNA methylation, and enhance risk of schizophrenia. The role of DNA methylation in contribution of environmental factors to etiology of schizophrenia is reviewed in this paper.

Key words: DNA methylation, environmental factor, schizophrenia