上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (6): 809-.doi: 10.3969/j.issn.1674-8115.2012.06.026

• 综述 • 上一篇    下一篇

趋化因子受体CCR5的研究进展

朱长斌1, 蒋子恺1, 程 枫2, 钱关祥3   

  1. 上海交通大学 1.医学院临床医学系, 上海 200025； 2.基础医学院教学实验中心, 上海200025； 3.基础医学院生物化学与细胞分子生物学系, 上海 200025
  • 出版日期:2012-06-28 发布日期:2012-07-02
  • 通讯作者: 程 枫, 电子信箱: jychengf@shsmu.edu.cn。
  • 作者简介:朱长斌（1989—）, 男, 07级临床医学八年制学生；电子信箱: zhu_changbin@hotmail.com。
  • 基金资助:

    上海市大学生创新性实验计划（09056）

Research progress of chemokine receptor CCR5

ZHU Chang-bin1, JIANG Zi-kai1, CHENG Feng2, QIAN Guan-xiang3   

  1. 1.School of Clinical Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China；2.Experiment Teaching Center, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China；3.Department of Biochemistry and Molecular Biology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2012-06-28 Published:2012-07-02
  • Supported by:

    Shanghai College Student Innovation Research Program, 09056

PDF (PC)

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摘要：

CCR5为趋化因子CC受体家族成员，属7次跨膜G蛋白耦联受体，配体为CCL3 （MIP-1α）、CCL4 （MIP-1β）、CCL5（RANTES）。CCR5主要表达于单核/巨噬细胞和淋巴细胞，与其配体介导CCR5+免疫细胞的趋化、募集过程。因此，多种免疫性疾病的发生和发展过程均有CCR5参与。CCR5是人类免疫缺陷病毒1型（HIV-1）入侵时的重要辅助受体，而在肿瘤细胞和各类肿瘤相关间质细胞的表面也可见其表达，并介导肿瘤增殖、浸润等多种生物学过程。随着相关研究技术的发展，进一步加深了对CCR5的结构、功能、信号通路及其在相关疾病中的作用的认识。

关键词: 趋化因子受体, CCR5, 免疫性疾病, 肿瘤

Abstract:

CCR5, as the member of CC receptor family, with its ligands being CCL3 (MIP-1α), CCL4 (MIP-1β) and CCL5 (RANTES), is categorized as 7 transmembrane domain G-protein coupled receptor. CCR5 is expressed in monocytes/macrophages as well as lymphocytes inducing chemotaxis and recruitment in inflammatory response and is an important co-receptor of human immunodeficiency virus (HIV)-1 virus, leading to the multifunction of CCR5 in progression of various kind of immunological diseases and invasion of HIV-1. Moreover, the expression of CCR5 on the surface of tumor cells and stromal cells contributes to mediating multiple biological behaviors of cancers such as proliferation and invasion. Advanced technologies also lead to the revealing of structure, function, signal transduction and roles of CCR5 in the progression of related diseases.

Key words: chemokine receptor, CCR5, immunological disease, cancer