›› 2009, Vol. 29 ›› Issue (11): 1341-.

• Original article (Basic research) • Previous Articles     Next Articles

Application of continuous cardiac index monitoring in acute heart failure model

ZHOU Jian, WU Xiao-yun, HAN Chen-jun, LI Zhou-bin, ZANG Wang-fu   

  1. Department of Cardiovascular Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2009-11-25 Published:2009-11-24
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 09441901300

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Abstract:

Objective To establish the swine acute heart failure model for surgical experiment, and evaluate the heart function by continuous cardiac index (CCI). Methods Swine heart failure model was attempted to establish by coronary ligation in six swines. CCI was obtained by Swan-Ganz catheters and Vigilance monitor, and hemodynamic, biochemical and ultrasonocardiographic results were utilized to evaluate the changes of heart function. Results Five swines accomplished the experiment. Compared with basic status, there were significant differences in mean arterial pressure (MAP), pulmonary artery systolic pressure (PASP), mixed venous oxygen saturation (SVO2) and CCI for swines with heart failure (P<0.05), there was no significant change in biochemical parameters, while left ventricle ejection fraction (LVEF) significantly decreased (P<0.05). Conclusion CCI is feasible in monitoring and evaluating heart function of animal model. The swine acute heart failure model established by coronary ligations can meet the needs of surgical experiment in principle.

Key words: continuous cardiac index, animal model, heart failure