Abstract:

Hypertension is a major contributor to the development of heart failure with normal left ventricular ejection fraction (HFNEF). Generally, hypertensive heart disease is a process of developing ventricular hypertrophy and fibrosis, which eventually leads to diastolic dysfunction and HFNEF. Now little is known about the process from hypertension to HFNEF, and this article explains the mechanisms from three factors of myocardial mechanisms, neuro-endocrinecytokine mechanisms and hemodynamic mechanisms.

Key words: hypertension, heart failure with normal left ventricular ejection fraction, mechanisms