Research advance in Notch signals in modulation of angiogenesis

›› 2010, Vol. 30 ›› Issue (5): 589-.

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Research advance in Notch signals in modulation of angiogenesis

JIANG Meng, reviewer；HE Ben, reviser

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China

Online:2010-05-25 Published:2010-05-28
Supported by:
National Natural Science Foundation of China, 30800453；Shanghai Rising-Star Program, 10QA1404500

Abstract

Abstract:

The research in roles of Notch signals in angiogenesis mainly concentrates on endothelial cell proliferation, regulation of ratio of tip cells to stalk cells, arterial-venous differentiation and perithelial cell mobilization. The research on Notch signals in angiogenesis may enable us to launch rational treatment targeting tissue ischemia, trauma and tumors. The composition of Notch signaling, roles and mechanism of Notch in physiological angiogenesis and application research on cord blood hematopoietic stem cells are reviewed in this paper.

Key words: Notch, angiogenesis, cord blood, hematopoietic stem cell

JIANG Meng. Research advance in Notch signals in modulation of angiogenesis[J]. , 2010, 30(5): 589-.

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Research advance in Notch signals in modulation of angiogenesis

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