›› 2013, Vol. 33 ›› Issue (1): 46-.doi: 10.3969/j.issn.1674-8115.2013.01.009

• Original article (Clinical research) • Previous Articles     Next Articles

Variation of drug susceptibility of Acinetobacter baumannii within 6 years and countermeasure analysis

XIAO Shu-zhen1, MI Chen-rong2, HAN Li-zhong1, CHEN Xu1, NI Yu-xing1   

  1. 1.Department of Clinical Microbiology, 2.Infection Control Department, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-01-28 Published:2013-02-06
  • Supported by:

    Special Fund for Health-scientific Research in the Public Interest, 201002021


Objective To investigate the clinical distribution and variation of drug resistance of Acinetobacter baumannii, and provide reference for antibiotic drug usage and infection control. Methods A total of 2 397 clinical isolates of Acinetobacter baumannii with result of drug sensitivity test were collected from Department of Clinical Microbiology of the hospital, and the distribution of isolates of Acinetobacter baumannii in clinical departments was analyzed. The sensitivity of Acinetobacter baumannii to 13 commonly used antibiotic drugs was determined by K-B method. Results There was no significant change in the distribution of clinical isolates of Acinetobacter baumannii within 6 years. The most common locations of Acinetobacter baumannii were Department of Burn, Department of Cardiothoracic Surgery, Department of Surgery, Department of Respirology, Department of Hematology and Department of Geriatrics. The sensitivity of Acinetobacter baumannii to commonly used antibiotic drugs generally descended. Isolates from section for outpatients and internal medicine departments were more sensitive to third-generation cephalosporin, fluoroquinolone and aminoglycosides, while strains from emergency department, surgical departments and intensive care unit (ICU) had a higher rate of drug resistance. Conclusion The sensitivity of Acinetobacter baumannii to antibiotic drugs decreases year by year, which should be paid more attention. Doctors should choose proper antibiotic drugs for different departments based on antimicrobial susceptibility results. Infection monitoring should be enhanced in hospitals to reduce the spread of drug-resistant bacteria.

Key words: Acinetobacter baumannii, resistance, infection, antibiotic drugs