›› 2013, Vol. 33 ›› Issue (1): 39-.doi: 10.3969/j.issn.1674-8115.2013.01.008

• Original article (Clinical research) • Previous Articles     Next Articles

Effect of different ovarian response after controlled ovarian hyperstimulation on pregnancy outcome of women undergoing in vitro fertilization

GAO Min-zhi1,2, SUN Zhao-gui3, ZHAO Xiao-ming1, ZHANG Hui-qin2,3, SUN Yun1   

  1. 1.Department of Reproductive Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China；2.Shanghai Medical College of Fudan University, Shanghai 200032, China；3.Shanghai Institution of Planned Parenthood Research, Shanghai 200032, China
  • Online:2013-01-28 Published:2013-02-06
  • Supported by:

    Shanghai Key Laboratory of Assisted Reproduction and Healthy Pregnancy Foundation, 12DZ2260600；Shanghai Science and Technology Committee Foundation,114119a1900, 12JC1405800

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Abstract:

Objective To investigate the effect of different ovarian response after controlled ovarian hyperstimulation (COH) on pregnancy outcome of women undergoing in vitro fertilization. Methods The clinical data of 1 310 women undergoing first cycle of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) due to male and/or tubal factor were analysed. According to the percentiles of serum E2 levels on the day of human chorionic gonadotrophin (hCG) administration, poor ovarian response group (group A, 0% to 10%), low-mid ovarian response group (group B, 11% to 25%), mid ovarian response group (group C, 26% to 75%), mid-high ovarian response group (group D, 76% to 90%) and high ovarian response group (group E, 91% to 100%) were divided. The numbers of oocytes retrieved, embryo development and pregnancy outcomes were compared among groups. Results The rate of clinical pregnancy was 44.73% for all the patients, and the implantation rate and abortion rate were 30.05% and 3.73% respectively. The numbers of MⅡ oocytes significantly increased from group A to group E (P<0.01). The numbers of goodquality embryos increased from group A to group E, and there were significant differences among groups (P<0.01) except for group D and group E. The numbers of embryos transfered in group A, group D and group E were significantly smaller than those in group B and group C (P<0.01). The cycle cancellation rate was the lowest in group C, and the cycle cancellation rates in group D and group E were significantly higher than those in group B and group C (P<0.05 or P<0.01). The pregnancy rates and implantation rates increased form group A to group C, and those decreased from group C to group E. The pregnancy rate and implantation rate in group C were significantly higher than those in group A and group E (P<0.05 or P<0.01). There was no significant difference in the abortion rate among groups (P>0.05). Conclusion Both low ovarian response and high ovarian response are detrimental to pregnancy outcome of women undergoing in vitro fertilization.

Key words: controlled ovarian hyperstimulation, in vitro fertilization/intracytoplasmic sperm injection-embryo transfer, ovarian response, endometrial receptivity, pregnancy