Abstract:

Objective To explore the potential feasibility of using urine metabolomics for diagnosing the major depression (MD) of patients with chronic hepatitis B. Methods Metabolites in the urine of 75 chronic hepatitis B patients with MD and 64 chronic hepatitis B patients without MD were detected by the nuclear magnetic resonance spectroscopy and analyzed by the orthogonal partial least-squares discriminant analysis (OPLS-DA). Results A total of 31 metabolites were identified. The results of OPLS-DA analysis showed that samples of two groups could be correctly separated by combinations of these metabolites (the accurate rate was about 88%). Twelve metabolites played a major role in separation. Conclusion Urine metabolomics has the potential feasibility for diagnosing the MD of patients with chronic hepatitis B and deserves further study and clinical application.

Key words: hepatitis B, urine, metabolomics, depression