Abstract:

Objective To explore the relevant influence factors and change trends and to set up normal reference value limits of glycated albumin (GA) of the gestation period through the study of serum GA of normal pregnant women. Methods A total of 1 046 normal pregnant women who presented to obstetric clinics of the Sixth People's Hospital affiliated to Shanghai Jiao Tong University between December, 2010 and February, 2013 were studied with prospective study. The method of percentiles was used to establish the reference range of GA. And t test and multiple linear regression analysis method were used to study the influential factors and change trend. Results ①For 1 046 normal pregnant women, simple correlation analysis showed that GA values of the gestation period of 12-16, 24-28, and 36-38 weeks were negatively correlated with pre-pregnancy BMI and weight gain during the gestation period (P<0.05), and there were no significant correlations between GA and age, birth weight, and gravidity and parity (P>0.05). Multiples stepwise regression analysis showed that pre-pregnancy BMI and weight gain during the gestation period were main influence factors of GA. ②Based on the pre-pregnancy BMI level, pregnant women were divided into three groups, i.e. low BMI group, normal BMI group, and overweight obesity group. The differences of GA level among groups were statistically significant (P<0.05) during 12-16, 24-28, and 36-38 weeks of gestation period. The differences of GA values of gestation periods were statistically significant (P<0.05). ③The values of GA between 2.5％ and 97.5％ of 1 046 normal pregnant women were selected as normal GA reference values of gestation period by the percentile method and the range of GA values was 9.20％-14.60％. The ranges of GA reference values of gestation periods of 12-16, 24-28, and 36-38 weeks were 10.20％-15.18%, 9.70％-13.98%, and 8.70％-13.20%, respectively. The GA values of different gestation periods were different for normal pregnant women with different pre-pregnancy BMI. Conclusion With the progress of the pregnancy, GA level gradually reduces. The normal reference range of the GA of gestation period can be suggested as 9.20%-14.60%. But influence factors such as the pre-pregnancy BMI, gestation period, and weight gain during gestation period should be considered for clinical applications.

Key words: pregnancy, glycated albumin, reference value, body mass index