Abstract:

Objective To compare the level of peripheral triglyceride between patients with major depressive disorder (MDD) and healthy control (HC) subjects by the meta analysis. Methods Case-control studies or cross-sectional studies relevant to patients with depression were retrieved from the PubMed, EMBASE, China National Knowledge Internet, Wanfang Data, VIP, and SinoMED. The deadline of retrieval time was October, 2013. The analysis was conducted by the Review Manager 5.0. Results Twenty-one papers from home and abroad were selected, which included 1 767 patients with depression and 1 950 healthy control subjects. The results of meta analysis indicated that triglyceride levels of patients with depression were 15.95 (95% confidence interval: 8.87-20.03) mg/dL (1 dL=100 mL), which were significantly higher than those of healthy control subjects (P<0.000 01). The subgroup analysis showed that antidepressants, age, and body mass index had certain effects on the triglyceride level. Conclusion The level of peripheral triglyceride of patients with depression elevates significantly and may be the risk factor of metabolic syndrome.

Key words: triglyceride, depression, meta analysis