›› 2015, Vol. 35 ›› Issue (10): 1502-.doi: 10.3969/j.issn.1674-8115.2015.10.014

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Correlation between response inhibition function and behavioral inhibition/activation systems of patients with obsessive-compulsive disorder

WANG Yuan, WANG Zhen, ZHANG Hai-yin, CHEN Jue, ZHAO Qing, XIAO Ze-ping   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030， China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    Medicine Guidance Project of Science and Technology Commission of Shanghai Municipality, 124119a8601； Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University, YG2013MS65； The National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873

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Abstract:

ObjectiveTo investigate the changes of response inhibition function of patients with obsessive-compulsive disorder (OCD) and its correlation with the activity of behavioral inhibition system/behavioral activation system (BIS/BAS).MethodsA total of 45 patients with OCD and 49 healthy controls were enrolled. The response inhibition function was assessed by the stop signal task (SST). BIS/BAS scale was used to perform the psychological assessment and the differences between two groups were compared.Results①SST: the stop signal reaction time (SSRT) of the OCD group [(351.16±48.18) ms] was significantly shorter than that of the control group [(389.65±30.47) ms](P<0.01). The rates of go success (GS) of the OCD group [(75.67±15.70)%] were significantly lower than those of the control group ([86.45±10.23)%](P<0.01). ②BIS/BAS scale: the scores of BIS of the OCD group (11.53±2.86) were significantly higher than those of the control group (9.39±3.32) (P<0.01). The difference of scores of BAS between two groups were not statistically significant (P>0.05). ③The scores of BIS of OCD patients with better response inhibtion function were significantly higher than those of other patients and controls (P<0.05).ConclusionThe response inhibition function of patients with OCD is enhanced and affected by the activity of BIS.

Key words: obsessive-compulsive disorder, behavioral inhibition system, behavioral activation system, stop signal task