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Research advances of structural proteins of sperm flagella

SONG Ping-ping, ZOU Sha-sha, LI Zheng, HU Hong-liang   

  1. Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    Foundation of Renji Hospital, Shanghai Jiao Tong University School of Medicine, RJZZ14-017; National Natural Science Foundations of China, 30973069, 30672146

Abstract:

The flagellum is the motility organ of mature sperms and its microtubule based axoneme structure is highly conservative during evolution. The defect or missing of sperm flagella protein, which is relevant to the structure and function of sperms, can lead to motility dysfunction of sperms and cause male infertility. This paper reviews the latest research advances of molecules relevant to the formation and motility of sperm tails. Problems of structure and function of these molecules are closely related to many clinical diseases.

Key words: sperm, flagellum, motility, protein