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Research progresses of the correlation between Rho/Rock signaling pathway and pulmonary fibrosis

QI Xiu-jie1,2, LI Jing3, TAN Li-ping1, XU Feng3, FANG Fang2   

  1. 1.Department of Emergency, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China; 2.Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Training Base of Clinical Resident Standard Training in Chongqing, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China; 3.Department of Pediatric Intensive Care Unit, Childrens Hospital of Chongqing Medical University, Chongqing 400014, China
  • Online:2016-10-28 Published:2016-11-29
  • Supported by:

    National Natural Science Foundation of China, 81101442

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Abstract:

Rho/Rock signaling pathway is a key signaling pathway regulating cell proliferation and tissue differentiation, as well as a signal transduction pathway moderating stem cell self-renewal process. Under the stimulation of a various inflammatory cytokines, Rho/Rock pathway is involved in biological behaviors such as cell contraction, chemotaxis, adhesion, and invasion via kinase cascade. Rho/Rock signaling transduction pathway is closely related to pulmonary fibrosis. Therefore, deep understanding of the effects and mechanisms of Rho/Rock pathway in pulmonary fibrosis may reveal novel breaking points for prevention and treatment of pulmonary fibrosis.

Key words: Rho, Rock, pathway, pulmonary fibrosis