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Expression of PPARγ in follicular thyroid carcinoma and its clinicopathological significance

JIAO Qiong1,2, HUANG Wen-tao2, LIU Liang2, GU Ming-min1, ZHANG Hui-zhen2   

  1. 1.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China； 2.Department of Pathology, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2016-10-28 Published:2016-11-29

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Abstract:

Objective·To explore the expression of peroxisome proliferator activated receptor γ(PPARγ) in follicular-patterned thyroid tumors. Methods·Follicular-patterned thyroid tumor samples from 194 cases that were diagnosed in recent two years were collected, including 60 cases of follicular carcinoma, 80 cases of benign adenoma, and 54 cases of atypical adenoma. The expression of PPARγ was measured by immunohistochemical staining (EnVision method). Results·The expression level of PPARγ gradually increased from benign adenoma to atypical adenoma and follicular carcinoma. The differences in strong positive PPARγ expression between follicular carcinoma and benign adenoma, and atypical adenoma and benign adenoma were statistically significant, while the difference between follicular carcinoma and atypical adenoma was not statistically significant. Conclusion·PPARγ is a specific immune marker for follicular carcinoma and important in the diagnosis of follicular carcinoma.

Key words: thyroid, follicular carcinoma, PPARγ