›› 2017, Vol. 37 ›› Issue (10): 1438-.doi: 10.3969/j.issn.1674-8115.2017.10.026

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Biomedical effects of TRIP-Br2

SHE Xin-ping, ZHENG Zhi   

  1. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2017-10-28 Published:2017-11-01
  • Supported by:
    National Natural Science Foundation of China, 81470643

Abstract: TRIP-Br2 (transcriptional regulator interacting with the PHD zinc finger and/or the bromodomain 2) is a kind of cell cycle regulator, which can specifically bind to transcription factor DP-1 (DRTF-1-polypeptide-1) and participate in E2F-1 (E2 factor-1)/DP-1-mediated transcriptional proliferative activities and maintain genome stability. As for energy metabolism, overexpression of TRIP-Br2 activates E2F-1/DP-1-mediated cell cycle regulation, leading to decreased genomic stability and promoting oncogenesis. High levels of TRIP-Br2 can induce brown adipocytes to release inflammatory factors and acute phase response proteins, producing inflammatory responses and acute phase responses. This paper summarizes the molecular structure of TRIPBr2 and its biological role in proliferation, metabolism, and inflammation.

Key words: TRIP-Br2, energy metabolism, neoplasm, inflammation