›› 2019, Vol. 39 ›› Issue (10): 1167-.doi: 10.3969/j.issn.1674-8115.2019.10.011

• Original article (Clinical research) • Previous Articles     Next Articles

Association of serum olanzapine concentration and cytochrome P450 1A2 gene polymorphisms: a meta-analysis

WANG Ye-wei, CHEN Yan, FANG Xin-yu, ZHANG Yi, CAI Jun, SONG Li-sheng, ZHANG Chen   

  1. Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200300, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    National Nature Science Foundation of China, 81000581, 81471358, 81771450; National Key Research and Development Program of China, 2018YFC1314302; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Funds, 12140904200; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152530

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Abstract: Objective · To investigate association of cytochrome P450 1A2 (CYP1A2) gene polymorphisms and serum olanzapine concentration. Methods · Key words including “cytochrome P450 CYP1A2”, “genetic polymorphism”, “antipsychotic”, “olanzapine”, “schizophrenia”, and “serum concentration” were used to search in databases, including SinoMed, Wanfang, Weipu, CNKI, PubMed, Embase and Cochrane Library. The search period was limited the establishment of the database to February 27th, 2018. STATA/SE 12.0 package was applied to conduct statistical analyses. Results · Four studies with a total of 330 schizophrenic patients were included. In the recessive model of CYP1A2 gene -163C>A SNP, patients with A/A genotype had significantly lower olanzapine concentration/dosage ratio (C/D) than patients with C/C or C/A genotype. Conclusion · A/A homozygote of CYP1A2 gene -163C>A SNP is significantly associated with the decreased olanzapine serum concentration.

Key words: cytochrome P450 1A2, olanzapine, serum drug concentrations, polymorphisms, meta-analysis

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