Review of circadian rhythm mechanism of lipid metabolism and its impact on the incidence of stroke

doi:10.3969/j.issn.1674-8115.2026.05.014

Abstract

Abstract:

Stroke, a cerebrovascular disease characterized by focal or global brain function impairment as its core clinical feature, is associated with high incidence, disability, and mortality rates. Its onset exhibits a certain circadian rhythmicity. With the acceleration of modern life rhythms and the development of science and technology, the prevalence of night-shift work and cross-time-zone travel has increased. Meanwhile, prolonged use of electronic products and extended entertainment time have led to an increase in the number of people with circadian rhythm disorders. Existing studies have confirmed that circadian rhythm disorders are significantly associated with the risk of various diseases, such as metabolic syndrome and cardiovascular and cerebrovascular diseases. However, the specific mechanisms remain unclear. Abnormal lipid metabolism is an important risk factor for stroke, especially ischemic stroke. The processes of lipid digestion, absorption, transport, synthesis, decomposition, and oxidation in the body are precisely regulated by central and peripheral molecular clocks, showing significant temporal characteristics. Circadian rhythm disorders are closely related to abnormal lipid metabolism and atherosclerosis. This article reviews the mechanisms by which circadian rhythms regulate lipid metabolism and their role in the onset and progression of stroke, and based on this, proposes new targets for stroke chronotherapy.

Key words: stroke, circadian rhythm, lipid metabolism, molecular clock, chronotherapy, atherosclerosis, dyslipidemia

CLC Number:

R743.3

Li Bei, Li Jingchen, Guo Xilang, Yu Yuansidu, Luo Yihong, Hu Qin, Gao Li. Review of circadian rhythm mechanism of lipid metabolism and its impact on the incidence of stroke[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(5): 672-679.

Figures/Tables 2

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References 49

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